9:40 AM 5/10/2020 - Covid-19 as the joint German-Russian Military Intelligence Operation - Michael Novakhov - SharedNewsLinks
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Covid-19 as the joint German-Russian Military Intelligence Operation - GS
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Michael Novakhov - SharedNewsLinks℠ | InBrief |
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Michael Novakhov - SharedNewsLinks℠ | InBrief |
Covid-19 as the joint German-Russian Military Intelligence Operation - GS
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Michael Novakhov - SharedNewsLinks℠ | InBrief |
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Michael Novakhov - SharedNewsLinks  | ||||
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| 9:14 AM 5/10/2020 - Military World Games in Wuhan in focus: We are all sick | There is no information about the members of the German and Russian team members getting sick at the Military World Games in Wuhan, while the members of many other European teams, e.g.: French, Spanish, Swedish, Italian, and the U.S. did get sick with the flu-like symptoms, apparently in the middle of the Games. - M.N. | Covid-19 is the joint German-Russian Military Intelligence Operation | ||||
https://tweetsandnews.blogspot.com/2020/05/914-am-5102020-military-world-games-in.html
_______________________________________________________________________  French army returned from Wuhan military games in October ... - GS ___________________________________________________________________________ There is no information about the members of the German and Russian team members getting sick at the Military World Games in Wuhan, while the members of many other European teams, e.g.: French, Spanish, Swedish, Italian, and the U.S. did get sick with the flu-like symptoms, apparently in the middle of the Games. - M.N. Military World Games in Wuhan in focus: We are all sick ______________________________________________________________________ » mikenov on Twitter: Covid-19 is the joint German-Russian Military Intelligence OPeration - Google Search google.com/search?q=Covid 10/05/20 06:00 from TWEETS BY MIKENOV from mikenova (1 sites) Covid-19 is the joint German-Russian Military Intelligence OPeration - Google Search google.com/search?q=Covid Posted by mikenov on Sunday, May 10th, 2020 10:00am mikenov on Twitter  Mike Nova's Shared NewsLinks Review In 250 Brief Posts -
» Military World Games in Wuhan in focus: We are all sick
10/05/20 08:41 from Mike Nova's Shared Newslinks Michael_Novakhov shared this story . © DIMITAR DILKOFF Matteo Tagliariol on the World Military Games in Wuhan Fencing Olympic champion Matteo Tagliariol already suspects the military world games held in Wuhan, China last October, as a ho...
» mikenov on Twitter: Military World Games in Wuhan in focus: We are all sick web24.news/u/2020/05/mili via @Web24 News
10/05/20 08:40 from TWEETS BY MIKENOV from mikenova (1 sites) Military World Games in Wuhan in focus: We are all sick web24.news/u/2020/05/mili via @Web24 News Posted by mikenov on Sunday, May 10th, 2020 12:40pm mikenov on Twitter
» mikenov on Twitter: In this regard, in a publication on the official website of the United States Department of Defense on October 25, it was mentioned that Maatje Benassi participated in a 50-mile bicycle race in Wuhan shortly before the outbreak. orinoc
10/05/20 08:37 from TWEETS BY MIKENOV from mikenova (1 sites) In this regard, in a publication on the official website of the United States Department of Defense on October 25, it was mentioned that Maatje Benassi participated in a 50-mile bicycle race in Wuhan shortly before the outbreak. orinocot...
» mikenov on Twitter: Did the US Military Games Delegation Spread COVID-19 in Wuhan? | Orinoco Tribune orinocotribune.com/did-the-us-mil
10/05/20 08:36 from TWEETS BY MIKENOV from mikenova (1 sites) Did the US Military Games Delegation Spread COVID-19 in Wuhan? | Orinoco Tribune orinocotribune.com/did-the-us-mil Posted by mikenov on Sunday, May 10th, 2020 12:36pm mikenov on Twitter
» mikenov on Twitter: American journalist, George Webb, claimed that an American military athlete, Maatje Benassi, a cyclist who was in Wuhan at the time for the cycling competition at the World Military Games, could have been COVID -19 patient zero in Wuha
10/05/20 08:36 from TWEETS BY MIKENOV from mikenova (1 sites) American journalist, George Webb, claimed that an American military athlete, Maatje Benassi, a cyclist who was in Wuhan at the time for the cycling competition at the World Military Games, could have been COVID -19 patient zero in Wuhan....
» mikenov on Twitter: Spanish athletes displayed coronavirus symptoms following the World Military Games in Wuhan in October 2019 - Olive Press News Spain theolivepress.es/spain-news/202
10/05/20 08:33 from TWEETS BY MIKENOV from mikenova (1 sites) Spanish athletes displayed coronavirus symptoms following the World Military Games in Wuhan in October 2019 - Olive Press News Spain theolivepress.es/spain-news/202 Posted by mikenov on Sunday, May 10th, 2020 12:33pm mikenov on Twitter
» Spanish athletes displayed coronavirus symptoms following the World Military Games in Wuhan in October 2019
10/05/20 08:32 from Mike Nova's Shared Newslinks Michael_Novakhov shared this story from Olive Press News Spain. SPANISH athletes returned from the World Military Games in Wuhan in October having displayed coronavirus symptoms. According to the Ministry of Defence none of the suspecte...
» mikenov on Twitter: Spanish athletes displayed coronavirus symptoms following the World Military Games in Wuhan in October 2019 theolivepress.es/spain-news/202 via @olivepress
10/05/20 08:31 from TWEETS BY MIKENOV from mikenova (1 sites) Spanish athletes displayed coronavirus symptoms following the World Military Games in Wuhan in October 2019 theolivepress.es/spain-news/202 via @olivepress Posted by mikenov on Sunday, May 10th, 2020 12:31pm mikenov on Twitter
» mikenov on Twitter: the-sun.com/news/791719/fe
10/05/20 08:30 from TWEETS BY MIKENOV from mikenova (1 sites) the-sun.com/news/791719/fe Posted by mikenov on Sunday, May 10th, 2020 12:30pm mikenov on Twitter
» mikenov on Twitter: She said a military doctor told the group, I think you had it because a lot of people from this delegation were ill. nypost.com/2020/05/07/ath
10/05/20 08:22 from TWEETS BY MIKENOV from mikenova (1 sites) She said a military doctor told the group, I think you had it because a lot of people from this delegation were ill. nypost.com/2020/05/07/ath Posted by mikenov on Sunday, May 10th, 2020 12:22pm mikenov on Twitter
» Fears coronavirus arrived in Europe in OCTOBER when French athletes at World Military Games in Wuhan brought it home The Sun
10/05/20 08:21 from Mike Nova's Shared Newslinks Michael_Novakhov shared this story from The Sun. Jump directly to the content Signed in as Michael_Novakhov Share this story on NewsBlur Shared stories are on their way...
» mikenov on Twitter: Athletes at World Military Games may have brought coronavirus to Europe nypost.com/2020/05/07/ath via @nypost
10/05/20 08:18 from TWEETS BY MIKENOV from mikenova (1 sites) Athletes at World Military Games may have brought coronavirus to Europe nypost.com/2020/05/07/ath via @nypost Posted by mikenov on Sunday, May 10th, 2020 12:18pm mikenov on Twitter
» mikenov on Twitter: It comes after Sweden's government epidemiologist Anders Tegnell said it was 'very natural' ... mol.im/a/8291755 via @MailOnline
10/05/20 08:17 from TWEETS BY MIKENOV from mikenova (1 sites) It comes after Sweden's government epidemiologist Anders Tegnell said it was 'very natural' ... mol.im/a/8291755 via @MailOnline Posted by mikenov on Sunday, May 10th, 2020 12:17pm mikenov on Twitter
» mikenov on Twitter: French media report that sick athletes were also noted in some other delegations, including ... mol.im/a/8291755 via @MailOnline
10/05/20 08:16 from TWEETS BY MIKENOV from mikenova (1 sites) French media report that sick athletes were also noted in some other delegations, including ... mol.im/a/8291755 via @MailOnline Posted by mikenov on Sunday, May 10th, 2020 12:16pm mikenov on Twitter
» mikenov on Twitter: Doctors have speculated that the virus might have been making its way around before even ... mol.im/a/8291755 via @MailOnline
10/05/20 08:14 from TWEETS BY MIKENOV from mikenova (1 sites) Doctors have speculated that the virus might have been making its way around before even ... mol.im/a/8291755 via @MailOnline Posted by mikenov on Sunday, May 10th, 2020 12:14pm mikenov on Twitter
» Did European athletes catch coronavirus while competing at World Military Games in Wuhan in OCTOBER?
10/05/20 07:31 from Mike Nova's Shared Newslinks Michael_Novakhov shared this story from News | Mail Online. French athletes believe they caught coronavirus at the World Military Games in Wuhan in October, 20 days before the first recorded case in China . It comes after it was revealed...
» mikenov on Twitter: Did European athletes catch coronavirus while competing at World Military Games in Wuhan in OCTOBER? French delegation returned with fevers
10/05/20 07:31 from TWEETS BY MIKENOV from mikenova (1 sites) Did European athletes catch coronavirus while competing at World Military Games in Wuhan in OCTOBER? French delegation returned with fevers Posted by mikenov on Sunday, May 10th, 2020 11:31am mikenov on Twitter
» mikenov on Twitter: Did European athletes catch COVID-19 at World Military Games in Wuhan mol.im/a/8291755 via @MailOnline
10/05/20 07:31 from TWEETS BY MIKENOV from mikenova (1 sites) Did European athletes catch COVID-19 at World Military Games in Wuhan mol.im/a/8291755 via @MailOnline Posted by mikenov on Sunday, May 10th, 2020 11:31am mikenov on Twitter
» mikenov on Twitter: French army returned from Wuhan military games in October ... - Google Search google.com/search?q=Frenc
10/05/20 07:28 from TWEETS BY MIKENOV from mikenova (1 sites) French army returned from Wuhan military games in October ... - Google Search google.com/search?q=Frenc Posted by mikenov on Sunday, May 10th, 2020 11:28am mikenov on Twitter
» mikenov on Twitter: French army left Wuhan military games in October with mystery illness mirror.co.uk/news/uk-news/f
10/05/20 07:19 from TWEETS BY MIKENOV from mikenova (1 sites) French army left Wuhan military games in October with mystery illness mirror.co.uk/news/uk-news/f Posted by mikenov on Sunday, May 10th, 2020 11:19am mikenov on Twitter
» mikenov on Twitter: French delegation at world military games in wuhan - Google Search google.com/search?q=Frenc
10/05/20 07:18 from TWEETS BY MIKENOV from mikenova (1 sites) French delegation at world military games in wuhan - Google Search google.com/search?q=Frenc Posted by mikenov on Sunday, May 10th, 2020 11:18am mikenov on Twitter
» mikenov on Twitter: US delegation at world military games in wuhan - Google Search google.com/search?q=US+de
10/05/20 07:17 from TWEETS BY MIKENOV from mikenova (1 sites) US delegation at world military games in wuhan - Google Search google.com/search?q=US+de Posted by mikenov on Sunday, May 10th, 2020 11:17am mikenov on Twitter
» mikenov on Twitter: German delegation at world military games in wuhan - Google Search google.com/search?q=Germa
10/05/20 07:16 from TWEETS BY MIKENOV from mikenova (1 sites) German delegation at world military games in wuhan - Google Search google.com/search?q=Germa Posted by mikenov on Sunday, May 10th, 2020 11:16am mikenov on Twitter
» mikenov on Twitter: a delegation consisting of 243 athletes competing in 21 sports for the event. Russia finished the event with 161 medals, just second behind to tournament hosts China's medal tally of 239. google.com/search?q=Russi
10/05/20 07:15 from TWEETS BY MIKENOV from mikenova (1 sites) a delegation consisting of 243 athletes competing in 21 sports for the event. Russia finished the event with 161 medals, just second behind to tournament hosts China's medal tally of 239. google.com/search?q=Russi Posted by mikenov on S...
» France fears virus may have spread in October after military games in Wuhan
10/05/20 07:11 from Mike Nova's Shared Newslinks Michael_Novakhov shared this story from oh dear somethings wrong! | news.com.au Australias #1 news site. France fears the killer coronavirus may have hit Europe from October as several athletes recall becoming very sick while comp...
» mikenov on Twitter: France fears virus may have spread as early as October news.com.au/world/coronavi via @newscomauHQ
10/05/20 07:11 from TWEETS BY MIKENOV from mikenova (1 sites) France fears virus may have spread as early as October news.com.au/world/coronavi via @newscomauHQ Posted by mikenov on Sunday, May 10th, 2020 11:11am mikenov on Twitter
» mikenov on Twitter: Coronavirus: France fears virus may have spread in October after military games in Wuhan news.com.au/world/coronavi
10/05/20 07:07 from TWEETS BY MIKENOV from mikenova (1 sites) Coronavirus: France fears virus may have spread in October after military games in Wuhan news.com.au/world/coronavi Posted by mikenov on Sunday, May 10th, 2020 11:07am mikenov on Twitter
» mikenov on Twitter: world military games in wuhan images.app.goo.gl/UaM6RPkbY2YpfT
10/05/20 07:02 from TWEETS BY MIKENOV from mikenova (1 sites) world military games in wuhan images.app.goo.gl/UaM6RPkbY2YpfT Posted by mikenov on Sunday, May 10th, 2020 11:02am mikenov on Twitter
» mikenov on Twitter: BBC News - Coronavirus: How lockdown is being lifted across Europe bbc.co.uk/news/explainer
10/05/20 06:53 from TWEETS BY MIKENOV from mikenova (1 sites) BBC News - Coronavirus: How lockdown is being lifted across Europe bbc.co.uk/news/explainer Posted by mikenov on Sunday, May 10th, 2020 10:53am mikenov on Twitter
» mikenov on Twitter: Early cases of Covid-19 in Europe - Google Search google.com/search?q=Early
10/05/20 06:38 from TWEETS BY MIKENOV from mikenova (1 sites) Early cases of Covid-19 in Europe - Google Search google.com/search?q=Early Posted by mikenov on Sunday, May 10th, 2020 10:38am mikenov on Twitter
» mikenov on Twitter: Needed: Truly independent probe of coronavirus devastation in NY nursing homes nypost.com/2020/05/09/nee via @nypost
10/05/20 06:30 from TWEETS BY MIKENOV from mikenova (1 sites) Needed: Truly independent probe of coronavirus devastation in NY nursing homes nypost.com/2020/05/09/nee via @nypost Posted by mikenov on Sunday, May 10th, 2020 10:30am mikenov on Twitter
» mikenov on Twitter: coronavirus in NY nursing homes - Google Search google.com/search?q=coron
10/05/20 06:29 from TWEETS BY MIKENOV from mikenova (1 sites) coronavirus in NY nursing homes - Google Search google.com/search?q=coron Posted by mikenov on Sunday, May 10th, 2020 10:29am mikenov on Twitter
» mikenov on Twitter: Covid-19 is the joint German-Russian Military Intelligence OPeration - Google Search google.com/search?q=Covid
10/05/20 06:00 from TWEETS BY MIKENOV from mikenova (1 sites) Covid-19 is the joint German-Russian Military Intelligence OPeration - Google Search google.com/search?q=Covid Posted by mikenov on Sunday, May 10th, 2020 10:00am mikenov on Twitter ______________________________________________________________________ Mike Nova's Shared NewsLinks Review In 250 Brief Posts -
» mikenov on Twitter: Covid-19 is the joint German-Russian Military Intelligence OPeration - Google Search google.com/search?q=Covid
10/05/20 06:00 from TWEETS BY MIKENOV from mikenova (1 sites) Covid-19 is the joint German-Russian Military Intelligence OPeration - Google Search google.com/search?q=Covid Posted by mikenov on Sunday, May 10th, 2020 10:00am mikenov on Twitter
» mikenov on Twitter: Tweets And News - From Michael Novakhov: » COVID-19: Alternative for use of saliva by bowle... tweetsandnews.blogspot.com/2020/05/covid-
10/05/20 05:56 from TWEETS BY MIKENOV from mikenova (1 sites) Tweets And News - From Michael Novakhov: » COVID-19: Alternative for use of saliva by bowle... tweetsandnews.blogspot.com/2020/05/covid- Posted by mikenov on Sunday, May 10th, 2020 9:56am mikenov on Twitter
» Tweets And News - From Michael Novakhov: » COVID-19: Alternative for use of saliva by bowlers likely: Gambhir 10/05/20 04:48 from Google Alert - saliva coronavirus test
10/05/20 05:56 from Blogs from Michael_Novakhov (19 sites) <a href="https://tweetsandnews.blogspot.com/2020/05/coronavirus-news-coronavirus-news.html" rel="nofollow">https://tweetsandnews.blogspot.com/2020/05/coronavirus-news-coronavirus-news.html</a> _________________________________________________________________________ CoronaVirus News CoronaVirus News Review In Brief » COVID-19: Alternative for use...
» mikenov on Twitter: Tweets And News - From Michael Novakhov: » President Trump announces federal government wil... tweetsandnews.blogspot.com/2020/05/presid
10/05/20 05:54 from TWEETS BY MIKENOV from mikenova (1 sites) Tweets And News - From Michael Novakhov: » President Trump announces federal government wil... tweetsandnews.blogspot.com/2020/05/presid Posted by mikenov on Sunday, May 10th, 2020 9:54am mikenov on Twitter
» Tweets And News - From Michael Novakhov: » President Trump announces federal government will buy $3 billion in meat, dairy & produce 09/05/20 22:03 from Google Alert - covid-19 in meat plants
10/05/20 05:53 from Blogs from Michael_Novakhov (19 sites) <a href="https://tweetsandnews.blogspot.com/2020/05/coronavirus-news-coronavirus-news.html" rel="nofollow">https://tweetsandnews.blogspot.com/2020/05/coronavirus-news-coronavirus-news.html</a> ____________________________________________________________________ CoronaVirus News CoronaVirus News Review In Brief » President Trump announces federal ...
» mikenov on Twitter: LGBTQ Americans are getting coronavirus, losing jobs. Anti-gay bias is making it worse for them. usatoday.com/story/news/nat via @usatoday
09/05/20 19:20 from TWEETS BY MIKENOV from mikenova (1 sites) LGBTQ Americans are getting coronavirus, losing jobs. Anti-gay bias is making it worse for them. usatoday.com/story/news/nat via @usatoday Posted by mikenov on Saturday, May 9th, 2020 11:20pm mikenov on Twitter
» mikenov on Twitter: Tweets And News - From Michael Novakhov: 5:10 PM 5/9/2020 - At the base of this lineage lie... tweetsandnews.blogspot.com/2020/05/510-pm
09/05/20 17:25 from TWEETS BY MIKENOV from mikenova (1 sites) Tweets And News - From Michael Novakhov: 5:10 PM 5/9/2020 - At the base of this lineage lie... tweetsandnews.blogspot.com/2020/05/510-pm Posted by mikenov on Saturday, May 9th, 2020 9:25pm mikenov on Twitter
» Tweets And News - From Michael Novakhov: 5:10 PM 5/9/2020 - At the base of this lineage lies the sample Germany/BavPat1/2020. This was "patient 1" in Bavaria who was infected by a business colleague visiting from China. This cluster was investigated via c
09/05/20 17:17 from Blogs from Michael_Novakhov (19 sites) <a href="https://tweetsandnews.blogspot.com/2020/05/510-pm-592020-at-base-of-this-lineage.html" rel="nofollow">https://tweetsandnews.blogspot.com/2020/05/510-pm-592020-at-base-of-this-lineage.html</a> ___________________________________________________________________ M.N.: Explanation, again: Coronavirus from this German "Patient 1" sample traveled ...
» mikenov on Twitter: RT @trvrb: Incredibly, it appears that this cluster containing Germany/BavPat1/2020 is the direct ancestor of these later viruses and thus
09/05/20 16:34 from TWEETS BY MIKENOV from mikenova (1 sites) Incredibly, it appears that this cluster containing Germany/BavPat1/2020 is the direct ancestor of these later viruses and thus led directly to some fraction of the widespread outbreak circulating in Europe today. 5/7 pic.twitter.com/mob...
» mikenov on Twitter: RT @trvrb: At the base of this lineage lies the sample Germany/BavPat1/2020. This was "patient 1" in Bavaria who was infected by a business
09/05/20 16:34 from TWEETS BY MIKENOV from mikenova (1 sites) At the base of this lineage lies the sample Germany/BavPat1/2020. This was "patient 1" in Bavaria who was infected by a business colleague visiting from China. This cluster was investigated via contact tracing and an analysis written her...
» mikenov on Twitter: Covid-19 Munich cluster - Google Search google.com/search?q=Covid
09/05/20 16:25 from TWEETS BY MIKENOV from mikenova (1 sites) Covid-19 Munich cluster - Google Search google.com/search?q=Covid Posted by mikenov on Saturday, May 9th, 2020 8:25pm mikenov on Twitter
» mikenov on Twitter: the Institute of Virology on Campus Charité Mitte in Berlin and the Bundeswehr Institute of Microbiology, an institution which forms part of the German Center for Infection Research (DZIF). sciencedaily.com/releases/2020/
09/05/20 16:18 from TWEETS BY MIKENOV from mikenova (1 sites) the Institute of Virology on Campus Charité Mitte in Berlin and the Bundeswehr Institute of Microbiology, an institution which forms part of the German Center for Infection Research (DZIF). sciencedaily.com/releases/2020/ Posted by mike...
» mikenov on Twitter: Coronavirus: Virological findings from patients treated in a Munich hospital sciencedaily.com/releases/2020/
09/05/20 16:15 from TWEETS BY MIKENOV from mikenova (1 sites) Coronavirus: Virological findings from patients treated in a Munich hospital sciencedaily.com/releases/2020/ Posted by mikenov on Saturday, May 9th, 2020 8:15pm mikenov on Twitter
» mikenov on Twitter: Covid-19 Munich cluster - Google Search google.com/search?q=Covid
09/05/20 15:39 from TWEETS BY MIKENOV from mikenova (1 sites) Covid-19 Munich cluster - Google Search google.com/search?q=Covid Posted by mikenov on Saturday, May 9th, 2020 7:39pm mikenov on Twitter
» Pass the salt: The minute details that helped Germany build virus defences
09/05/20 15:37 from Mike Nova's Shared Newslinks Michael_Novakhov shared this story . MUNICH (Reuters) - One January lunchtime in a car parts company, a worker turned to a colleague and asked to borrow the salt. As well as the saltshaker, in that instant, they shared the new coronaviru...
» mikenov on Twitter: Covid-19 Germany Bavaria Munich cluster patient 1 - who is he? - Google Search google.com/search?q=Covid
09/05/20 15:35 from TWEETS BY MIKENOV from mikenova (1 sites) Covid-19 Germany Bavaria Munich cluster patient 1 - who is he? - Google Search google.com/search?q=Covid Posted by mikenov on Saturday, May 9th, 2020 7:35pm mikenov on Twitter | ||||
| 5:10 PM 5/9/2020 - At the base of this lineage lies the sample Germany/BavPat1/2020. This was "patient 1" in Bavaria who was infected by a business colleague visiting from China. This cluster was investigated via contact tracing and an analysis ... Incredibly, it appears that this cluster containing Germany/BavPat1/2020 is the direct ancestor of these later viruses and thus led directly to some fraction of the widespread outbreak circulating in Europe today... | ||||
 https://tweetsandnews.blogspot.com/2020/05/510-pm-592020-at-base-of-this-lineage.html ___________________________________________________________________ M.N.: Explanation, again: Coronavirus from this German "Patient 1" sample traveled most likely, from Munich to Wuhan, and not the other way around. Or these were two independent cases with two different, unrelated to each other by origin, viruses. ____________________________________ "At the base of this lineage lies the sample Germany/BavPat1/2020. This was "patient 1" in Bavaria who was infected by a business colleague visiting from China. This cluster was investigated via contact tracing and an analysis..." "Incredibly, it appears that this cluster containing Germany/BavPat1/2020 is the direct ancestor of these later viruses and thus led directly to some fraction of the widespread outbreak circulating in Europe today..." _____________________________________________________________________ Mike Nova's Shared NewsLinks Review In 250 Brief Posts -
» mikenov on Twitter: RT @trvrb: Incredibly, it appears that this cluster containing Germany/BavPat1/2020 is the direct ancestor of these later viruses and thus
09/05/20 16:34 from TWEETS BY MIKENOV from mikenova (1 sites) Incredibly, it appears that this cluster containing Germany/BavPat1/2020 is the direct ancestor of these later viruses and thus led directly to some fraction of the widespread outbreak circulating in Europe today. 5/7 pic.twitter.com/mob...
» mikenov on Twitter: RT @trvrb: At the base of this lineage lies the sample Germany/BavPat1/2020. This was "patient 1" in Bavaria who was infected by a business
09/05/20 16:34 from TWEETS BY MIKENOV from mikenova (1 sites) At the base of this lineage lies the sample Germany/BavPat1/2020. This was "patient 1" in Bavaria who was infected by a business colleague visiting from China. This cluster was investigated via contact tracing and an analysis written her...
» mikenov on Twitter: Covid-19 Munich cluster - Google Search google.com/search?q=Covid
09/05/20 16:25 from TWEETS BY MIKENOV from mikenova (1 sites) Covid-19 Munich cluster - Google Search google.com/search?q=Covid Posted by mikenov on Saturday, May 9th, 2020 8:25pm mikenov on Twitter
» mikenov on Twitter: the Institute of Virology on Campus Charité Mitte in Berlin and the Bundeswehr Institute of Microbiology, an institution which forms part of the German Center for Infection Research (DZIF). sciencedaily.com/releases/2020/
09/05/20 16:18 from TWEETS BY MIKENOV from mikenova (1 sites) the Institute of Virology on Campus Charité Mitte in Berlin and the Bundeswehr Institute of Microbiology, an institution which forms part of the German Center for Infection Research (DZIF). sciencedaily.com/releases/2020/ Posted by mike...
» mikenov on Twitter: Coronavirus: Virological findings from patients treated in a Munich hospital sciencedaily.com/releases/2020/
09/05/20 16:15 from TWEETS BY MIKENOV from mikenova (1 sites) Coronavirus: Virological findings from patients treated in a Munich hospital sciencedaily.com/releases/2020/ Posted by mikenov on Saturday, May 9th, 2020 8:15pm mikenov on Twitter
» mikenov on Twitter: Covid-19 Munich cluster - Google Search google.com/search?q=Covid
09/05/20 15:39 from TWEETS BY MIKENOV from mikenova (1 sites) Covid-19 Munich cluster - Google Search google.com/search?q=Covid Posted by mikenov on Saturday, May 9th, 2020 7:39pm mikenov on Twitter
» Pass the salt: The minute details that helped Germany build virus defences
09/05/20 15:37 from Mike Nova's Shared Newslinks Michael_Novakhov shared this story . MUNICH (Reuters) - One January lunchtime in a car parts company, a worker turned to a colleague and asked to borrow the salt. As well as the saltshaker, in that instant, they shared the new coronaviru...
» mikenov on Twitter: Covid-19 Germany Bavaria Munich cluster patient 1 - who is he? - Google Search google.com/search?q=Covid
09/05/20 15:35 from TWEETS BY MIKENOV from mikenova (1 sites) Covid-19 Germany Bavaria Munich cluster patient 1 - who is he? - Google Search google.com/search?q=Covid Posted by mikenov on Saturday, May 9th, 2020 7:35pm mikenov on Twitter
» mikenov on Twitter: Bavaria cluster patient 1 - Google Search google.com/search?q=Bavar
09/05/20 15:25 from TWEETS BY MIKENOV from mikenova (1 sites) Bavaria cluster patient 1 - Google Search google.com/search?q=Bavar Posted by mikenov on Saturday, May 9th, 2020 7:25pm mikenov on Twitter
» mikenov on Twitter: Full sequence, BetaCoV/Munich/BavPat1/2020, from Bavaria cluster patient 1 deposited at GISAID. - Google Search google.com/search?q=Full+
09/05/20 15:23 from TWEETS BY MIKENOV from mikenova (1 sites) Full sequence, BetaCoV/Munich/BavPat1/2020, from Bavaria cluster patient 1 deposited at GISAID. - Google Search google.com/search?q=Full+ Posted by mikenov on Saturday, May 9th, 2020 7:23pm mikenov on Twitter
» mikenov on Twitter: Was sample - Germany/BavPat1/2020 sequence deposited on 28th. - from Bavaria? - Google Search google.com/search?q=Was+s
09/05/20 15:22 from TWEETS BY MIKENOV from mikenova (1 sites) Was sample - Germany/BavPat1/2020 sequence deposited on 28th. - from Bavaria? - Google Search google.com/search?q=Was+s Posted by mikenov on Saturday, May 9th, 2020 7:22pm mikenov on Twitter
» mikenov on Twitter: mutation at 614th position of the Spike protein (D614G) ... was from Germany (Germany/BavPat1/2020 sequence deposited on 28th - Google Search google.com/search?q=mutat
09/05/20 15:17 from TWEETS BY MIKENOV from mikenova (1 sites) mutation at 614th position of the Spike protein (D614G) ... was from Germany (Germany/BavPat1/2020 sequence deposited on 28th - Google Search google.com/search?q=mutat Posted by mikenov on Saturday, May 9th, 2020 7:17pm mikenov on Twitter
» mikenov on Twitter: mutation at 614th position of the Spike protein (D614G) ... was from Germany - (Germany/BavPat1/2020 sequence deposited on 28thD614G mutation Germany - Google Search google.com/search?q=D614G
09/05/20 15:17 from TWEETS BY MIKENOV from mikenova (1 sites) mutation at 614th position of the Spike protein (D614G) ... was from Germany - (Germany/BavPat1/2020 sequence deposited on 28th D614G mutation Germany - Google Search google.com/search?q=D614G Posted by mikenov on Saturday, May 9th, 202...
» mikenov on Twitter: D614G mutation Germany - Google Search google.com/search?q=D614G
09/05/20 15:16 from TWEETS BY MIKENOV from mikenova (1 sites) D614G mutation Germany - Google Search google.com/search?q=D614G Posted by mikenov on Saturday, May 9th, 2020 7:16pm mikenov on Twitter
» mikenov on Twitter: Coronavirus strain with D614G mutation was disseminated from Germany - Google Search google.com/search?newwind
09/05/20 14:54 from TWEETS BY MIKENOV from mikenova (1 sites) Coronavirus strain with D614G mutation was disseminated from Germany - Google Search google.com/search?newwind Posted by mikenov on Saturday, May 9th, 2020 6:54pm mikenov on Twitter
» mikenov on Twitter: Presently dominant Coronavirus with D614G mutation strain was disseminated from Germany - Google Search google.com/search?newwind
09/05/20 14:52 from TWEETS BY MIKENOV from mikenova (1 sites) Presently dominant Coronavirus with D614G mutation strain was disseminated from Germany - Google Search google.com/search?newwind Posted by mikenov on Saturday, May 9th, 2020 6:52pm mikenov on Twitter
» mikenov on Twitter: Presently dominant Coronavirus D614G strain was disseminated from Germany - Google Search google.com/search?newwind
09/05/20 14:49 from TWEETS BY MIKENOV from mikenova (1 sites) Presently dominant Coronavirus D614G strain was disseminated from Germany - Google Search google.com/search?newwind Posted by mikenov on Saturday, May 9th, 2020 6:49pm mikenov on Twitter
» mikenov on Twitter: The researchers found that a version of the virus, which was first detected in Europe in early February, appears to have become the most common strain in the U.S., Australia, parts of Africa basically, anywhere it spread. npr.org/sec
09/05/20 14:33 from TWEETS BY MIKENOV from mikenova (1 sites) The researchers found that a version of the virus, which was first detected in Europe in early February, appears to have become the most common strain in the U.S., Australia, parts of Africa basically, anywhere it spread. npr.org/secti...
» mikenov on Twitter: This week, the question of mutation has been front and center in coverage of the coronavirus from controversial claims about changes that make the virus more contagious to reassurances that any mutations are not yet consequential. np
09/05/20 14:31 from TWEETS BY MIKENOV from mikenova (1 sites) This week, the question of mutation has been front and center in coverage of the coronavirus from controversial claims about changes that make the virus more contagious to reassurances that any mutations are not yet consequential. npr.... | ||||
| 8:19 AM 5/9/2020 - "Pass the salt", but the other way around: from Germany to China! (Or vice versa!) - Was coronavirus spreading in Europe last year? "UK got many of its coronavirus cases from Europe, rather than China"... | According to Alessandro Vespignani, a professor at Northeastern University in Boston, the novel coronavirus was already circulating in major US cities in January. | The version of the coronavirus now gripping the UK and Europe is more infectious than the one that triggered the pandemic in China, according to scientists. | ||||
 https://tweetsandnews.blogspot.com/2020/05/819-am-592020-pass-salt-but-other-way.html "Pass the salt", but the other way around: from Germany to China! (Or vice versa!) - Was coronavirus spreading in Europe last year? - Google Search
On Tuesday, 5 May, Britains chief scientific adviser, Patrick Vallance, told MPs that genome sequencing suggests that the UK got many of its coronavirus cases from Europe, rather than China.
"One of the things that it looks like, very clearly, is that early in March the UK got many, many different imports of virus from many different places," he said.
"And those places were particularly from European countries with outbreaks.
"And so we see a big influx of cases, probably from Italy and Spain, looking at the genomics of the virus in early March, seeded right the way across the country, and so whether that was people returning from half-term, whether it's business travellers or not we don't know, but a lot of the cases in the UK didn't come from China and didn't come from the places you might have expected.
"They actually came from European imports and the high level of travel into the UK around that time."
Questions have been raised about a Champions League match with Atletico Madrid in Liverpool in March and whether it increased the spread of coronavirus in the city.
Liverpool and the greater region have suffered disproportionately from coronavirus.
On 11 March, 3,000 fans travelled from Madrid for the clash with Liverpool, at a time when they were not permitted to watch their own team play at home, as all La Liga matches were ordered to be played behind closed doors, without fans present.
...According to Alessandro Vespignani, a professor at Northeastern University in Boston, the novel coronavirus was already circulating in major US cities in January. _______________________________________________________________________ The version of the coronavirus now gripping the UK and Europe is more infectious than the one that triggered the pandemic in China, according to scientists. PUBLISHED: 14:53 EDT, 5 May 2020 | UPDATED: 02:25 EDT, 6 May 2020
Believed to have originated in China or Europe the version of the virus, dubbed G614, is now 'the dominant pandemic form in many countries', the scientists said.
They said it was first found in Germany in February and had since become the most common form of the virus in patients worldwide - it appears to force out the older version whenever they clash.
 M.N.: My interpretation of this phenomenon. (I hypothesized it earlier, before this study, which appears to confirm it). The Epidemic in China was introduced first (either by the Germans - the New Abwehr, or by the Russian GRU, or both, which is most likely) as the cover and the diversion: to create the element of confusion and to make the true detection and understanding more difficult, in order to give the pandemic more time to develop and to spread around. After the Epidemic developed in Wuhan, Germany evacuated 150 of its citizens, on a special military plane; and Russia evacuated 600, most of whom, very likely, were their agents, who possibly started the Epidemic there. The effects of the strict surveillance in China and South Korea can be explained not by the "social distancing" and tracing the cases so much, as by the putting the stop to the intentional criminal spread, by whatever means it was done. Furthermore, the patterns of the new cases in China and South Korea appear to be very different from the rest of the world, as it was described in the previous post. I named this pattern as the "Preliminary Wave".   Note the February 14-16 spikes on China, and March 1 on South Korea graphs. I call them the Valentine and the Ides of March greeting cards. They probably were the messages, predicting the future Pandemic. The real Epidemics, from Europe, with G614 strain followed soon, most likely via air travel from the Oktoberfest and the other "Karnevals". It looks like these are the different illnesses, with practically the different pathogens and different clinical picture, more severe and more transmissible in the case of G614 (the "European") strain. This also poses the questions about the validity and usefulness of the antigen tests if they were based on the Chinese samples. The preponderance of this strain in Italy indicates that it was imported more easily and more readily from Germany. A certain skepticism regarding the B. Korber's - Los Alamos study were expressed. Did a Mutation Turbocharge the Coronavirus? Not Likely, Scientists Say - NYT. Dr. Scott Gottlieb says coronavirus mutation study doesnt prove new strain more contagious See also: Version of the virus, dubbed G614 - GS G614 strain of Coronavirus was found in Germany - GS ________________________________________________________________________ Mike Nova's Shared NewsLinks Review In 250 Brief Posts-
» mikenov on Twitter: "Dr. Scott Gottlieb says coronavirus mutation study doesnt prove new strain more contagious" cnbc.com/2020/05/06/dr-
09/05/20 10:00 from TWEETS BY MIKENOV from mikenova (1 sites) "Dr. Scott Gottlieb says coronavirus mutation study doesnt prove new strain more contagious" cnbc.com/2020/05/06/dr- Posted by mikenov on Saturday, May 9th, 2020 2:00pm mikenov on Twitter
» mikenov on Twitter: BBC News - Coronavirus mutations: Scientists puzzle over impact bbc.co.uk/news/health-52
09/05/20 09:57 from TWEETS BY MIKENOV from mikenova (1 sites) BBC News - Coronavirus mutations: Scientists puzzle over impact bbc.co.uk/news/health-52 Posted by mikenov on Saturday, May 9th, 2020 1:57pm mikenov on Twitter
» mikenov on Twitter: The newer strain named G614 (blue) appeared later on in the pandemic but, since then, has ... mol.im/a/8289673#i-b5 via @MailOnline
09/05/20 09:00 from TWEETS BY MIKENOV from mikenova (1 sites) The newer strain named G614 (blue) appeared later on in the pandemic but, since then, has ... mol.im/a/8289673#i-b5 via @MailOnline Posted by mikenov on Saturday, May 9th, 2020 1:00pm mikenov on Twitter
» mikenov on Twitter: The mutation Spike D614G is of urgent concern; after beginning to spread in Europe in early February, when introduced to new regions it repeatedly and rapidly becomes the dominant form. biorxiv.org/content/10.110
09/05/20 08:59 from TWEETS BY MIKENOV from mikenova (1 sites) The mutation Spike D614G is of urgent concern; after beginning to spread in Europe in early February, when introduced to new regions it repeatedly and rapidly becomes the dominant form. biorxiv.org/content/10.110 Posted by mikenov on Sa...
» mikenov on Twitter: Spike mutation pipeline reveals the emergence of a more transmissible form of SARS-CoV-2 biorxiv.org/content/10.110
09/05/20 08:58 from TWEETS BY MIKENOV from mikenova (1 sites) Spike mutation pipeline reveals the emergence of a more transmissible form of SARS-CoV-2 biorxiv.org/content/10.110 Posted by mikenov on Saturday, May 9th, 2020 12:58pm mikenov on Twitter
» mikenov on Twitter: Did a Mutation Turbocharge the Coronavirus? Not Likely, Scientists Say nytimes.com/2020/05/06/hea
09/05/20 08:57 from TWEETS BY MIKENOV from mikenova (1 sites) Did a Mutation Turbocharge the Coronavirus? Not Likely, Scientists Say nytimes.com/2020/05/06/hea Posted by mikenov on Saturday, May 9th, 2020 12:57pm mikenov on Twitter
» Coronavirus: Europe and UK strain more infectious than China's
09/05/20 08:44 from Mike Nova's Shared Newslinks Michael_Novakhov shared this story from News | Mail Online. The version of the coronavirus now gripping the UK and Europe is more infectious than the one that triggered the pandemic in China , according to scientists. Researchers in the...
» mikenov on Twitter: According to Alessandro Vespignani, a professor at Northeastern University in Boston, the novel coronavirus was already circulating in major US cities in January. rte.ie/news/2020/0508
09/05/20 08:38 from TWEETS BY MIKENOV from mikenova (1 sites) According to Alessandro Vespignani, a professor at Northeastern University in Boston, the novel coronavirus was already circulating in major US cities in January. rte.ie/news/2020/0508 Posted by mikenov on Saturday, May 9th, 2020 12:38p...
» mikenov on Twitter: Scientists in the US are also investigating hidden outbreaks of Covid-19 before the official "first" case was declared on 21 January. rte.ie/news/2020/0508
09/05/20 08:37 from TWEETS BY MIKENOV from mikenova (1 sites) Scientists in the US are also investigating hidden outbreaks of Covid-19 before the official "first" case was declared on 21 January. rte.ie/news/2020/0508 Posted by mikenov on Saturday, May 9th, 2020 12:37pm mikenov on Twitter | ||||
| Military World Games in Wuhan in focus: We are all sick | ||||
© DIMITAR DILKOFF Matteo Tagliariol on the World Military Games in Wuhan Fencing Olympic champion Matteo Tagliariol already suspects the military world games held in Wuhan, China last October, as a hotspot of the corona pandemic. When we arrived in Wuhan, we were all sick. All six people in my apartment were sick, including many athletes from other delegations, the 37-year-old Italian told the Corriere della Sera newspaper. The Military World Games were held in Wuhan from October 18-27, 2019. The first case of infection was officially reported in China in December. However, there is speculation that the coronavirus has already spread. I had a severe cough, many other athletes had a fever, said Tagliariol, who won gold in epee fencing in Beijing in 2008. The worst awaited him when he returned to Italy. I had a very high fever and could not breathe. Antibiotics did not help either. I was sick and very weak for three weeks. Then my two-year-old son Leo fell ill. He coughed for three weeks. My partner also got sick, but in When I started talking about the virus, I thought: I was infected. I recognized the symptoms of COVID 19. I am an athlete, I was very bad for my standards, said Tagliariol. Almost 10,000 athletes from more than 140 countries had participated in the Military World Games in Wuhan, from Germany there were 243 athletes. More than 230,000 volunteers were involved in the competitions. According to LEquipe, French pentathlete Elodie Clouvel and Valentin Belaud are also likely to have been infected at the Wuhan games. The World Military Games have been held every four years by the Military World Sports Association since 1995, modeled on the Olympic Games in summer and every four years in winter since 2010. The Summer Games always take place one year before the Summer Olympics, the Winter Games are held in the same year. | ||||
| Spanish athletes displayed coronavirus symptoms following the World Military Games in Wuhan in October 2019 | ||||
SPANISH athletes returned from the World Military Games in Wuhan in October having displayed coronavirus symptoms. According to the Ministry of Defence none of the suspected victims had been tested. The Spanish team was made up of about 170 people. According to Ministry sources who spoke to El Mundo, two athletes displayed flu-like symptoms during the Games between October 17-28 and two others displayed them upon their return to Spain. One of these athletes told El Mundo: The authorities just took it as a sore throat or flu infection and they treated us as if we were already cured, it was very bad. China only informed the World Health Organisation (WHO) of the extent of the seriousness of COVID-19 on December 31, 65 days after the end of the World Military Games. This week, after symptoms emerged in the French military from the Games, Spanish team leaders asked the athletes who participated in Wuhan if they had shown any signs of the pandemic. The Ministry of Defence was not aware of any of its participants in the Games displaying any symptoms and its too late to test them now. They did however state that the Spanish delegation was not housed near the French one. | ||||
| Fears coronavirus arrived in Europe in OCTOBER when French athletes at World Military Games in Wuhan brought it home The Sun | ||||
 | ||||
| Did European athletes catch coronavirus while competing at World Military Games in Wuhan in OCTOBER? | ||||
French athletes believe they caught coronavirus at the World Military Games in Wuhan in October, 20 days before the first recorded case in China.
It comes after it was revealed that Frenchman Amirouche Hammar, 43, had been infected with COVID-19 outside Paris as early as December. The hospital where Hammar was treated for chest pains has since re-tested samples and found the fishmonger was positive for the virus on December 27. It is not known where he caught the virus, although his wife works close to Charles de Gaulle airport. A number of French athletes who were at the World Military Games from October 18 to 27 have since described coming down with severe flu-like symptoms while at the event. Elodie Clouvel, a world champion modern pentathlete, was asked on March 25 whether she was anxious about spending the summer in Japan for the Olympics. She told Loire 7: 'No because I think that with Velentin (Belaud, her partner, also a pentathlete) we have already had the coronavirus, well the COVID-19.'
Elodie Clouvel, 31, won gold at the World Military Games which took place in Wuhan between October 18 and 27 - she believes she and her partner, along with other athletes, caught the virus
Amirouche Hammar (pictured) has revealed himself as the French patient who had coronavirus as early as December 27
Elodie Clouvel told French media she wasn't concerned about competing at the Olympics in Japan because she'd already had the virus
The 31-year-old went on: 'We were in Wuhan for the World Military Games at the end of October. And afterwards, we all fell ill. Valentin missed three days of training. Me, I was sick too. [...] I had things I had never had before. We weren't particularly worried because no one was talking about it yet.'French 'patient zero' had COVID-19 in December
Amirouche Hammar came forward after a hospital near Paris revealed it had re-tested old flu samples and found a positive test for coronavirus on December 27.
The Algerian-born fish market worker had not travelled to China, and the result suggests the virus was spreading in France well before January 24 when the country confirmed its first case. Speaking to BFMTV, Hammar said he had suffered 'very serious' chest pains but said doctors had been mystified by his illness before eventually diagnosing a lung infection. Although experts have urged caution about the findings, the WHO said today it was 'not surprising' that a case had occurred in December and said that more such discoveries were possible. 'It's also possible there are more early cases to be found,' WHO spokesman Christian Lindmeier told a UN briefing in Geneva. Hammar's wife works at a supermarket near Charles de Gaulle Airport in Paris where passengers are known to go shopping after they land. The doctor who revealed the case said the patient's wife had worked at a fish market with Chinese colleagues. The French delegation were competing in the 7th World Military Games in Wuhan - just 20 days before the first Chinese person officially became ill with coronavirus - with 402 athletes present, along with 10,000 other athletes from all over the world. According to French news channel BFMTV, a number of athletes returned to France with unusual symptoms, including fevers and body aches. According to the news channel, none of the returning athletes was tested and the French Army who were responsible for organising their athletes at the military games reportedly confirmed that they had not wanted to test any athletes either. Doctors have speculated that the virus might have been making its way around before even December, in November or even in October, and the latest revelations seem to underscore that. BFMTV quotes one athlete, who preferred to remain anonymous, as saying that he originally thought he had simply caught a cold. However, when news began to emerge of an epidemic in Wuhan, many athletes on a WhatsApp group reportedly began to openly wonder if it was possible that they had contracted the disease too. Now that it has been revealed that Amirouche Hammar in France had the coronavirus back in December, closer attention is being paid to what these athletes have said.
The French delegation were competing in the 7th World Military Games in Wuhan - just 20 days before the first Chinese person officially became ill with coronavirus - with 402 athletes present, along with 10,000 other athletes from all over the world
Clouvel said: 'We were in Wuhan for the World Military Games at the end of October. And afterwards, we all fell ill. Valentin missed three days of training. Me, I was sick too. [...] I had things I had never had before. We weren't particularly worried because no one was talking about it yet.' (pictured: Clouvel with her partner)
Clouvel told French media in March: 'A lot of athletes at the World Military Games were very ill. We were recently in touch with a military doctor who told us: "I think you had it because a lot of people from this delegation were ill."'
Share this articleShare701 shares According to French media, athletes who were in Wuhan reportedly received telephone calls from the army a few weeks ago to reassure them. One of these athletes, who also preferred to remain anonymous, is quoted as saying: 'We were told: there is no risk, you left on 28th October and the virus arrived on 1st November.' French media report that sick athletes were also noted in some other delegations, including the Swedish delegation, with people returning to Sweden with strong fevers. Around 100 people from the Swedish Armed Forces attended the World Military Games in Wuhan and stayed in the city for two weeks. Several competitors fell ill and were screened for the virus, although none were reported to have tested positive. It comes after Sweden's government epidemiologist Anders Tegnell said it was 'very natural' to assume that coronvirus was spreading in Scandinavia from November. Tegnell told Sweden's TT news agency: 'There wasn't any spread [of infection] outside Wuhan until we saw it in Europe later.
State epidemiologist Anders Tegnell (pictured above) claimed individual cases would have been detected among travellers from Wuhan
'But I think that you could find individual cases among Wuhan travellers who were there in November to December last year. That doesn't sound at all strange, but rather very natural.'Sweden - one of just a handful of countries to resist a lockdown - has no plans to implement large-scale sample testing of patients who received care for respiratory symptoms or flu last year to see if they had coronavirus. The country's first official coronavirus case was a woman in Jönköping who tested positive on January 31st after a trip to China. The woman has since recovered from the illness.
Chinese scientists doing research in controversial Wuhan virus lab
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| France fears virus may have spread in October after military games in Wuhan | ||||
France fears the killer coronavirus may have hit Europe from October as several athletes recall becoming very sick while competing in Wuhan back then.
It's now thought that the bug was unleashed in Europe months before the Chinese city in Hubei Province became infamous as the world's original COVID-19 epicentre, according to The Sun.
International athletes who gathered at the World Military Games in Wuhan last October may have brought the killer bug back home with them, French media say. Le Parisian writes that several athletes complained of symptoms upon their return, and that in hindsight, "they may have contracted COVID-19". Elodie Clouvel, a world champion modern pentathlete, was asked on local TV station Television Loire 7 on March 25 if she was worried about the prospect of potentially having to spend the summer in Japan for the Olympics. She replied: "No because I think that with Velentin [Belaud, her partner, also a pentathlete] we have already had the coronavirus, well the COVID-19." 'MISSED TRAINING The 31-year-old added: "We were in Wuhan for the World Military Games at the end of October. "And afterwards, we all fell ill. "Valentin missed three days of training. "Me, I was sick too. I had things I had never had before. We weren't particularly worried because no-one was talking about it [back then]." RELATED: Follow more coronavirus news She added: "A lot of athletes at the World Military Games were very ill. "We were recently in touch with a military doctor who told us: 'I think you had it because a lot of people from this delegation were ill.'" This new revelation comes after it was discovered that a Frenchman, Amirouche Hammar, 43, had been infected with the coronavirus in the Paris region as early as December 27.
Amirouche Hammar fell ill with the coronavirus in December. Picture: AP/Michel EulerSource:AP
RELATED: Flu samples find first French case in DecemberThe French delegation took part in the 7th edition of the World Military Games in Wuhan from October 18-27 last year just 20 days before the first Chinese person officially became ill with coronavirus with 402 athletes present, along with 10,000 other athletes from across the globe. According to French news channel BFMTV, a number of athletes returned to France with unusual symptoms, including fevers and body aches. However, none of the returning athletes were tested. The French Army who were responsible for organising their athletes at the military games reportedly confirmed that they had not wanted to test any athletes either. THOUGHT IT WAS A COLD Doctors have speculated that the virus might have been spreading in France before December in November or even as far back as October and the latest French media revelations seem to underscore that. BFMTV quoted one anonymous athlete saying that he originally thought he had simply caught a cold. But, when news began to emerge of an epidemic in Wuhan, many athletes on a WhatsApp group reportedly began to openly wonder if it was possible that they had previously contracted the disease too. Now that it has been revealed that Amirouche Hammar in France had the coronavirus back in December, closer attention is being paid to what those athletes have said. Local media report that since Elodie Clouvel spoke up on March 25, many athletes have been told not to answer journalists' questions and to refer media inquiries to the head of communication of the French armies.
French athletes at the World Military Games in Wuhan in 2019. Picture: TwitterSource:Supplied
According to the French media, athletes who were in Wuhan reportedly received telephone calls from the army a few weeks ago to reassure them.One of these athletes, who also preferred to remain anonymous, said: "We were told there is no risk, you left on 28th October and the virus arrived on 1st November. But, given the confusion over when exactly the new coronavirus was unleashed, and revelations from an Associated Press investigation that China didn't warn the public of the likely pandemic for six key days, there are mounting fears that it may have spread beyond its boundaries far earlier than first reported. QUESTIONABLE TIMELINE President Xi Jinping warned the public on January 20. But by that time, more than 3,000 people had been infected in China alone. The Chinese government has repeatedly denied suppressing information in the early days, saying it immediately reported the outbreak to the World Health Organisation (WHO). French media report that sick athletes were also noted in some other military teams, including the Swedish delegation, with people returning to Sweden with strong fevers. Frenchman Amirouche Hammar said he went to hospital while suffering "very serious" pains in his chest and difficulty breathing.
Frenchman Amirouche Hammar had the coronavirus back in December. Picture: BFMTVSource:Supplied
The 42-year-old fishmonger from Algeria has lived in France for years and had no recent travel history. Picture: AP/Michel EulerSource:AP
He is now known to have had coronavirus in December, after samples taken late last year were retested and a positive case found.Doctors initially concluded he had a lung infection, and Mr Hammar recovered after spending several days in hospital. It is not known how Mr Hammar, who has no links to China, caught the bug, but his wife works on the fish counter of a supermarket near Charles de Gaulle Airport in Paris. The finding suggests that the virus arrived in Europe and began to spread long before it was identified and understood as a public health emergency. France officially confirmed its first coronavirus case on January 24, exactly four weeks after the sample that has now tested positive was taken. In an interview with BMFTV, Mr Hammar said he initially thought he had flu, but went to the Avicenne hospital, in the Paris suburbs, after his symptoms became worse. This story originally appeared on The Sun and has been republished with permission. | ||||
| Pass the salt: The minute details that helped Germany build virus defences | ||||
MUNICH (Reuters) - One January lunchtime in a car parts company, a worker turned to a colleague and asked to borrow the salt.
That their exchange was documented at all is the result of intense scrutiny, part of a rare success story in the global fight against the virus. The co-workers were early links in what was to be the first documented chain of multiple human-to-human transmissions outside Asia of COVID-19, the disease caused by the coronavirus. They are based in Stockdorf, a German town of 4,000 near Munich in Bavaria, and they work at car parts supplier Webasto Group. The company was thrust under a global microscope after it disclosed that one of its employees, a Chinese woman, caught the virus and brought it to Webasto headquarters. There, it was passed to colleagues - including, scientists would learn, a person lunching in the canteen with whom the Chinese patient had no contact. The Jan. 22 canteen scene was one of dozens of mundane incidents that scientists have logged in a medical manhunt to trace, test and isolate infected workers so that the regional government of Bavaria could stop the virus from spreading. That hunt has helped Germany win crucial time to build its COVID-19 defences. The time Germany bought may have saved lives, scientists say. Its first outbreak of locally transmitted COVID-19 began earlier than Italys, but Germany has had many fewer deaths. Italys first detected local transmission was on Feb. 21. By then Germany had kicked off a health ministry information campaign and a government strategy to tackle the virus which would hinge on widespread testing. In Germany so far, more than 2,100 people have died of COVID-19. In Italy, with a smaller population, the total exceeds 17,600. We learned that we must meticulously trace chains of infection in order to interrupt them, Clemens Wendtner, the doctor who treated the Munich patients, told Reuters. Wendtner teamed up with some of Germanys top scientists to tackle what became known as the Munich cluster, and they advised the Bavarian government on how to respond. Bavaria led the way with the lockdowns, which went nationwide on March 22. Scientists including Englands Chief Medical Officer Chris Whitty have credited Germanys early, widespread testing with slowing the spread of the virus. We all know Germany got ahead in terms of its ability to do testing for the virus and theres a lot to learn from that, he said on TV earlier this week. Christian Drosten, the top virologist at Berlins Charite hospital, said Germany was helped by having a clear early cluster. Because we had this Munich cohort right at the start ... it became clear that with a big push we could inhibit this spreading further, he said in a daily podcast for NDR radio on the coronavirus. Drosten, who declined to be interviewed for this story, was one of more than 40 scientists involved in scrutiny of the cluster. Their work was documented in preliminary form in a working paper at the end of last month. The paper, not yet peer-reviewed, was shared on the NDR site. ELECTRONIC DIARIESIt was on Monday, Jan. 27, that Holger Engelmann, Webastos CEO, told the authorities that one of his employees had tested positive for the new coronavirus. The woman, who was based in Shanghai, had facilitated several days of workshops and attended meetings at Webastos HQ.The womans parents, from Wuhan, had visited her before she travelled on Jan. 19 to Stockdorf, the paper said. While in Germany, she felt unusual chest and back aches and was tired for her whole stay. But she put the symptoms down to jet lag. She became feverish on the return flight to China, tested positive after landing and was hospitalised. Her parents also later tested positive. She told her managers of the result and they emailed the CEO. In Germany, Engelmann said he immediately set up a crisis team that alerted the medical authorities and started trying to trace staff members who had been in contact with their Chinese colleague. The CEO himself was among them. Just four or five days before I received the news, I had shaken hands with her, he said. Now known as Germanys Case #0, the Shanghai patient is a long-standing, proven employee from project management who Engelmann knows personally, he told Reuters. The company has not revealed her identity or that of others involved, saying anonymity has encouraged staff to co-operate in Germanys effort to contain the virus. The task of finding who had contact with her was made easier by Webasto workers electronic calendars for the most part, all the doctors needed was to look at staff appointments. It was a stroke of luck, said Wendtner, the doctor who treated the Munich patients. We got all the information we needed from the staff to reconstruct the chains of infection. For example, case #1 - the first person in Germany to be infected by the Chinese woman - sat next to her in a meeting in a small room on Jan. 20, the scientists wrote. Where calendar data was incomplete, the scientists said, they were often able to use whole genome sequencing, which analyses differences in the genetic code of the virus from different patients, to map its spread. By following all these links, they discovered that case #4 had been in contact several times with the Shanghai patient. Then case #4 sat back-to-back with a colleague in the canteen. When that colleague turned to borrow the salt, the scientists deduced, the virus passed between them. The colleague became case #5. Webasto said on Jan. 28 it was temporarily closing its Stockdorf site. Between Jan. 27 and Feb. 11, a total of 16 COVID-19 cases were identified in the Munich cluster. All but one were to develop symptoms. Bavaria closed down public life in mid-March. Germany has since closed schools, shops, restaurants, playgrounds and sports facilities, and many companies have shut to aid the cause. HAMMER AND DANCEThis is not to say Germany has defeated COVID-19.Its coronavirus death rate of 1.9%, based on data collated by Reuters, is the lowest among the countries most affected and compares with 12.6% in Italy. But experts say more deaths in Germany are inevitable. The death rate will rise, said Lothar Wieler, president of Germanys Robert Koch Institute for infectious diseases. The difference between Germany and Italy is partly statistical: Germanys rate seems so much lower because it has tested widely. Germany has carried out more than 1.3 million tests, according to the Robert Koch Institute. It is now carrying out up to 500,000 tests a week, Drosten said. Italy has conducted more than 807,000 tests since Feb. 21, according to its Civil Protection Agency. With a few local exceptions, Italy only tests people taken to hospital with clear and severe symptoms. Germanys government is using the weeks gained by the Munich experience to double the number of intensive care beds from about 28,000. The country already has Europes highest number of critical care beds per head of the population, according to a 2012 study. Even that may not be enough, however. An Interior Ministry paper sent to other government departments on March 22 included a worst-case scenario with more than 1 million deaths. Another scenario saw 12,000 deaths - with more testing after partial relaxation of restrictions. That scenario was dubbed hammer and dance, a term coined by blogger Tomas Pueyo. It refers to the hammer of quick aggressive measures for some weeks, including heavy social distancing, followed by the dance of calibrating such measures depending on the transmission rate. The German government paper argued that in the hammer and dance scenario, the use of big data and location tracking is inevitable. Such monitoring is already proving controversial in Germany, where memories of the East German Stasi secret police and its informants are still fresh in the minds of many. A subsequent draft action plan compiled by the government proposes the rapid tracing of infection chains, mandatory mask-wearing in public and limits on gatherings to help enable a phased return to normal life after Germanys lockdown. The government is backing the development of a smartphone app to help trace infections. Germany has said it will re-evaluate the lockdown after the Easter holiday; for the car parts maker at the heart of its first outbreak, the immediate crisis is over. Webastos office has reopened. All 16 people who caught COVID-19 there have recovered.
Joern Poltz reported from Munich, Paul Carrel from Berlin; Additional reporting by Markus Wacket in Berlin and Gavin Jones in Rome; Edited by Sara Ledwith
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| Coronavirus: Europe and UK strain more infectious than China's | ||||
The version of the coronavirus now gripping the UK and Europe is more infectious than the one that triggered the pandemic in China, according to scientists.
Researchers in the US and Britain studied the viruses taken from patient samples and found that the West seems to have been hit by a mutated version of the original. They said the mutated form of the virus appears more infectious and spreads faster but it does not seem to affect how seriously ill someone becomes. It also raises the prospect that the virus is able to mutate in a way that could - over time - lead to fundamental chances which reduce the likelihood of natural immunity of the effectiveness of a vaccine. Believed to have originated in China or Europe the version of the virus, dubbed G614, is now 'the dominant pandemic form in many countries', the scientists said. They said it was first found in Germany in February and had since become the most common form of the virus in patients worldwide - it appears to force out the older version whenever they clash. Viruses mutate naturally all the time and it is not usually cause for alarm but should be studied in case they change so much they become unrecognisable to the body and immunity from a first infection cannot protect against them, as is the case with flu. The research comes as British scientists today revealed in a Government study that there were at least a dozen different strains circulating in the population in March.
The newer strain named G614 (blue) appeared later on in the pandemic but, since then, has dominated the older, slower-spreading strain D614 (orange) in most areas of the world. It was the only one recorded in England but all the patients sampled were taken from one city - Sheffield
Most countries outbreaks began with the older D614 strain (shown in orange). In China and Singapore this remained the dominant strain but in most countries worldwide it was edged out in March by the mutated G614 version
The study was done by scientists at the University of Sheffield and Los Alamos National Laboratory, New Mexico, and published openly online.It focused on a mutation of the virus, officially named SARS-CoV-2, which was referred to as D614G. The researchers referred to the viruses without the mutation as D614 and the version with it as G614. It is not clear whether they classify as separate strains because the mutation is so small and affects only one tiny part of the virus. Looking at samples from around the world they found that D614 appeared to have been the virus's original state in humans, and the one found in Wuhan. It made up the vast majority of all COVID-19 infections in China, and Asia as a whole, and also seemed to be the first version of the virus to appear in the countries they studied. However, the mutated version - G614 - started to appear soon after in Europe and North America in particular, before going on to take over as the dominant virus.
Raab: 'Social distancing has been a success in this delicate moment'
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LIVEProgress: 0% 0:00 Share this articleShare2.2k shares 'In most countries and states where the COVID-19 epidemic was initiated and where sequences were sampled prior to March 1, the D614 form was the dominant local form early in the epidemic. 'Wherever G614 entered a population, a rapid rise in its frequency followed, and in many cases G614 became the dominant local form in a matter of only a few weeks.' They said the G614 mutation may give the virus a 'selective advantage' which makes it better able to bind to cells in the airways, or to shed viruses which it uses to reproduce and spread. It could do this because the D614G mutation appeared to affect the shape of the 'spike' protein that the virus uses to attach to a person's cells and infect them. A sample of 447 hospital patients in Sheffield showed that people had a higher viral load when infected with G614, meaning they had a higher quantity of viruses circulating in their body. This could make them more likely to spread COVID-19 because they could be more likely to show symptoms and have more viruses on their breath, for example. The researchers wrote: 'An early April sampling... showed that G614's frequency was increasing at an alarming pace throughout March, and it was clearly showing an ever-broadening geographic spread.' And they added: 'Through March, G614 became increasingly common throughout Europe, and by April it dominated contemporary sampling. 'In North America, infections were initiated and established across the continent by the original D614 form, but in early March, the G614 was introduced into both Canada and the USA, and by the end of March it had become the dominant form in both nations.' The researchers added that the fact that the spike protein is such a key target for vaccines and medication, means that this apparent evidence it can mutate was cause for concern. If a vaccine is developed to target the virus by latching onto its spike protein, for example, that would become useless if the protein changed shape. And the same principle applies to natural immunity - if the body learns to attack viruses with a spike protein that is one shape, it may not recognise or react to a virus with one that takes a different form. Dr Jonathan Stoye, from The Francis Crick Institute, said: 'Although the functional significance of the changes observed have yet to be fully characterised, the study shows that SARS-CoV-2 can alter its genetic structure in multiple ways as it spreads around the world, a finding likely to have important implications for vaccine development.' Scientists are still not sure whether people develop long-term immunity after their first bout of COVID-19. Sir Patrick Vallance, the UK's chief scientific adviser, said it is very unlikely that people would develop total protection after recovering from the illness.
Milan adjusts to new social norms as Italy eases lockdown
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Although the older D614 strain (orange) managed to remain dominant in Asia for most of the pandemic, it was quickly superseded by the mutated version in Western countries and Africa, which started recording outbreaks later on
The Sheffield research comes as SAGE, the British Government's Scientific Advisory Group for Emergencies, today published a paper revealing that at least a dozen strains of the coronavirus were circulating in the UK in March.It is not clear whether G614 is included in this research. The scientists who did that study used different names for the strains they studied, and the research was done earlier than the G614 study. In it, leading genetic scientists had analysed the genomes of the killer virus in 260 infected patients from all corners of the UK. They say they identified 12 unique versions of the virus, one of which has only ever been found in Britain meaning it mutated on UK soil. But the COVID-19 Genomics UK Consortium (COG-UK) said the number of strains is very likely substantially higher due to under-sampling in the UK. The scientists say most of the strains were imported from Italy and Spain, the worst-hit countries in the world at the time the research was carried out. There is no suggestion that any of the strains are any more potent or infectious than another, infectious disease experts say. Professor Paul Hunter, at the University of East Anglia, told MailOnline it is 'entirely plausible' this could happen to one of the strains if it continues to evolve. The report, made public today, was given to the Government's Scientific Advisory Group for Emergencies (Sage) in March to help them map the outbreak's spread. Other secret documents of scientific evidence that helped shape the Government's response to the crisis were released today.
Patrick Vallance says face masks could curb the spread of Covid-19
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There are at least a dozen different strains of coronavirus ravaging the UK. The most common is the B.12.1 strain (pink) and the B.11 strain (green). The researchers did not make clear which strains were imported from other countries, nor did it disclose which one is unique to Britain
New mutation of COVID-19 suggests the disease is weakening
Scientists have discovered a unique mutation to coronavirus in Arizona - and it's a pattern that they've seen before.
One of the 382 samples they collected from coronavirus patients in the state was missing a sizeable segment of genetic material. In the middle and late stages of the SARS epidemic of 2003, this very same kind of deletion started cropping up in patients around the globe. It's not just any mutation - the change robs the closely related viruses of one of their weapons against the host's immune response, making the infection weaker. As that mutation became widespread, the SARS outbreak wound down. By July - five months after it emerged in Asia in February 23 - there were no new cases, and the outbreak was considered contained. Now, Arizona State University experts have only found one person who had a version of the virus with this mutation - but they say if genome sequencing for coronavirus become more common, we may find far more. They sequenced the genomes of the virus in 382 nasal swab samples. Like ours, viral genetic material is composed of chemical units known by their letters. The human genome consists of three billion DNA 'letters'. Viral genomes are far simpler than ours, and coronavirus consists of 30,000 letters of RNA. In one of the samples they collected, the ASU researchers discovered that a massive 81 letters were missing. And these were a particularly meaningful missing 81 pieces of RNA. 'This is something we've seen before in the 2003 SARS outbreak during the middle and late phase of the outbreak, the virus acquired large deletions in these SS3 proteins,' lead study author Dr Efrem Lim told <a href="http://DailyMail.com" rel="nofollow">DailyMail.com</a>. 'These proteins are not just there to replicate - they are in there to help enhance virulence and suppress the immune system [of the host]. It evolved with a more attenuated from in the late phase of the epidemic.' In other words, the SARS virus changed to be weaker (attenuated viruses are less the less risky, modified versions researchers make in labs as the basis for vaccines) as time went on. And now, at least one sample of SARS-CoV-2 had done the same. All viruses mutate slightly as they spread through populations, which leads to small changes in their genetic material. Scientists say the virus does this to overcome immune system resistance in different communities. As part of the study, COG-UK researchers analysed patients in Belfast, Birmingham, Cambridge, Cardiff, Edinburgh, Exeter, Glasgow, Liverpool, London, Norwich, Nottingham, Oxford and Sheffield. They found 12 unique strains, most of which had been imported from Europe. The report did not specify which countries, but said the majority of cases came from Italy. It found that strains had also come from China, the US and Australia. Professor Hunter told MailOnline: 'There are a number of issues with these strains - are they likely to cause different severity of disease? Are they likely to be more infectious? And are they capable of invalidating vaccines? 'The answer to all three of these is that we have no idea. There is no suggestion from this study - or any other that I have read - that show these strains are more virulent or infectious that one another. 'But it is plausible that one strain could mutate to the point where people with antibodies to an older strain are no longer immune to it. 'These are called escape mutants, because they escape from the control of immunity. 'It happens with influenza a lot. The current coronavirus does not seem to do this as fast, though, but it is plausible down the line.' Professor Hunter said the main value of the report was that it helps scientists track the spread of the infection around the UK. He said this would become crucial when easing out of lockdown. Professor Hunter added: 'This enables researchers to continue to track where its going and help enforce new rules to stop another outbreak. 'Say you have a cluster in the north west of England, which is unexpected, and it is the same strain found predominantly in London, then you could see that is must've been spread by someone travelling from the capital. 'You could use this to tell if someone had broken lockdown rules by travelling there, or you could close down a possible transmission passage [a train line, for example].'
Sir patrick Vallance told MPs: 'But a lot of the cases in the UK didnt come from China and didn't come from the places you might have expected'
The COG-UK is an innovative partnership of NHS organisations, the four Public Health Agencies of the UK, the Wellcome Sanger Institute and more than 12 academic institutions, including Cambridge University.It is supported by £20million funding from the UK Department of Health and Social Care (DHSC), UK Research and Innovation (UKRI) and the Wellcome Trust. Coronavirus has mutated to become deadlier in Europe, Chinese study claims
There could be as many as 30 different strains of coronavirus, a study of patients in China has claimed.
Zhejiang University scientists studied a small number of patients with the disease and uncovered tens of mutations - 19 of which had never been seen before. Some mutations boosted the virus' ability to invade cells in the body, others helped the disease multiply more rapidly. The most deadly strains were genetically similar to the ones that spread in Europe and in New York, reported the South China Morning Post. Meanwhile, the weaker strains were similar to those found circulating within other parts of the US, such as Washington State. The authors say their findings - based on just 11 patients - are the first to show the mutation could affect the severity of illness. They believe the previously unreported mutations could be the reason behind Europe and New York's devastating death tolls. It is still unclear why the aggressive strain of COVID-19 spread to Europe and the more mild version hit large swathes of the US. But scientists say viruses are constantly mutating to overcome immune system resistance in different populations. It comes on the heels of studies that claim the US was hit by two different clusters of the coronavirus, with type A dominating the West Coast and the deadlier type B in New York. Experts say the type A outbreak was spread to the US from China, where as the crisis in New York likely came from Europe - which was also rocked by type B. For the latest study, published on the pre-print service medRxiv.org, the team analyzed viral strains from 11 Chinese coronavirus patients. The team, conducted by Professor Li Lanjuan and colleagues, tested how effectively the virus could infect and kill human cells in the laboratory. Viral load - the amount of the virus - was assessed in all the cells after one, two, four and eight hours, as well as the next day and 48 hours later. And the experts also looked at the cytopathic effects - whether the virus structurally changed the cell during infection - up to three days after the experiment. The most aggressive strains created up to 270 times as much viral load as the least potent type, according to the results. And the strains that produced the highest viral load led to a 'higher cell death ratio', Professor Li and her team revealed. Writing in their paper, the team said: 'Our results show the observed mutations can have a direct impact on the viral load and CPE. 'This finding suggests the observed mutations in our study... can significantly impact the pathogenicity (the ability to cause disease) of SARS-CoV-2.' The team found some of the deadliest mutations in Zhejiang, where the university is located. These mutations had also been seen in several hard-hit European countries such as Italy and Spain - before spreading to the US epicenter New York. However, some of the milder mutations were the varieties largely found in the US, including Washington state, which could be the strain that shut down Wuhan, where the virus originated. But the scientists admitted that the 'full mutational diversity of the virus in Wuhan in the early days is still unknown'. The occupants of three flights from the outbreak ground zero in the Chinese city of Wuhan and another bringing home passengers from a cruise ship of Japan were the only ones taken to secure facilities in the UK. But millions more entering the UK between the start of 2020 and March 22 were able to enter freely and only advised to self-isolate, according to figures obtained by the Guardian. It came as it also emerged the UK suffered a 'big influx' of coronavirus from arrivals from Italy and Spain who were not quarantined. Mapping of the Covid-19 genome shows that UK cases come from all over the world, chief scientific adviser Sir Patrick Vallance told MPs. But a large number of cases in early March were from Europe and 'seeded right the way across the country' because Brits arriving back in the UK were allowed to return home. Giving evidence to the Health and Social Care Committee this morning, Sir Patrick said that experts on the Scientific Advisory Group for Emergencies (Sage) had advised ministers they would have to be 'extremely draconian' in blocking travel from whole countries otherwise 'it really was not worth trying to do it.' 'Whether that was people returning from half-term, whether it is business travellers or not, we dont know,' he told MPs. 'But a lot of the cases in the UK didnt come from China and didn't come from the places you might have expected. 'They actually came from European imports and the high level of travel into the UK around that time.' At the weekend a senior minister finally confirmed visitors to the UK could face time in quarantine as the Government 'actively' considers stronger anti-coronavirus measures at the borders. Transport Secretary Grant Shapps said that new arrivals could also be forced to download a new contract app onto their smartphone as a condition of entry. New restrictions would make the UK one of the last countries to introduce them, with the country very much an outlier in recent weeks by not halting inbound flights or insisting arrivals are checked. People arriving are currently advised to self-isolate but there is no enforced testing. Home Secretary Priti Patel is believed to be among those who have demanded tougher rules for foreign visitors and the remaining Brits still abroad who make it home. But Sir Patrick suggested stopping travel was of limited use unless action was taken against a wide-range of countries. 'What was very clear, and I think you can see this now in retrospect, is that the idea that you can control this by stopping travel from one place doesnt work unless it is of course the only source of import,' he said this morning. 'We have now in the UK sequenced 13,6000 viral genomes, we got imports from all over the place. 'So quite early on the advice Sage gave was ''if you are going to do something on travel you either need to be extremely draconian - stop all travel from all sorts of countries - or it is really not worth trying to do it, trying to stop from one place because you wont make it happen''. 'So I think the answer is not, unless the country chose to do that, stopping travel anywhere and to make sure that as people come back you have appropriate systems to isolate and make sure they are following the same rules as the rest of the country.' Deputy chief medical officer Dr Jenny Harries, who was also giving evidence, added: 'There are pros and cons which are not necessarily always obvious I think, between managing influx and outflux of passengers but also goods. 'If you shut travel routes in, you are also shutting routes for various products which may be essential, not just for our population but all around the world. 'At the moment most people who are coming back are coming back into the UK back home and they will immediately fall under social distancing regulations anyway.'
Chris Whitty warns of the possibility of a second coronavirus peak
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| Was coronavirus spreading in Europe last year? | ||||
Coronavirus. A word so familiar to us all, it's almost lost its meaning, except for the fact that it has changed our lives so drastically.
But when did this new strain of coronavirus begin to take hold? In January, the novel coronavirus was very much a foreign story, as it spread out from the Chinese city of Wuhan. The first death was recorded in Wuhan on 11 January, the first death outside China occurring two days later in Thailand, one week later, the first US case of infection; in Washington. Until now, the first human-to-human transmission within Europe was thought to have been a German man that was infected by a Chinese colleague who visited Germany between 19 and 22 January. But what if coronavirus was already spreading across the world as early as December? What would be the significance of an earlier spread of the disease? Were many more people infected in those early days when the world thought it was just a problem for China? On 3 May, medics working at a Paris hospital announced that they had discovered that a patient they treated last December for flu-like symptoms had actually had COVID-19.  French researchers led by Yves Cohen, head of resuscitation at the Avicenne and Jean Verdier hospitals, retested samples from 24 patients treated in December and January who had tested negative for flu. The results, published in the International Journal of Antimicrobial Agents, showed that one patient - a 42-year-old man born in Algeria, who had lived in France for many years - was infected with COVID-19 "one month before the first reported cases in our country". Speaking to local station, BFMTV, Amirouche Hammar described the days before he went to hospital. The resident of the Bobigny suburb of Paris described his symptoms: dry cough, fever, fatigue and serious trouble breathing. At first, the now 43-year-old says he thought it was the flu, but after several days of feeling ill, he went to the emergency department on 27 December. This was the end of 2019 when the virus had apparently only affected China. On 31 December, China alerted the World Health Organisation about several cases of an unusual pneumonia in Wuhan with unknown cause. Three days later, 44 patients were reported to the WHO, which made an announcement on social media the following day. The medical team which treated Mr. Hammar were faced with a quandary when it came to diagnosing the father of four. Eventually, they declared a pulmonary infection. It wasnt until May, however, that Mr Hammar learned that he had actually been infected by the infamous coronavirus. The 43-year-old was contacted by Professor Yves Cohen to tell him that a swab taken from him in December had tested positive for Covid-19. How did Covid-19 show up in a patient in Paris when it hadnt officially been declared in China? Speaking to the BBC, Professor Cohen says they looked at whether the patient had any links to China, which he hadnt. His wife works at a fish-counter in a supermarket, but it doesn't sell any fish from China. However, the team discovered that she works in close proximity to a sushi counter staffed by a number of Asian employees. The team queried whether she might have contracted it from someone who had travelled to China and brought it home while remaining asymptomatic. Speaking to BFMTV, Fatiha Hammar put forward another theory. The supermarket where she works is near Charles de Gaulle Airport and is frequented by people who come directly from the airport with their suitcases. She wondered whether that was another possible source of infection. What does this tell us about the virus? Simply that it could have originated in France back in December, which is important. But do we know whether it means that the French case is not linked to Wuhan? Professor Cohen says its too early to tell. If further investigations find a link with the sushi-counter staff, then a connection to Wuhan could be definitively found. This virus sample will be examined to see if it's got a similar genomic sequence to those in Wuhan. If not, it would point to other contamination sources worldwide, which would complicate the search for a vaccine, because wed be dealing with other types of virus. While news of a potential "patient zero" in France has sparked much interest, experts advise caution, and further investigation. Virologist at Queens University Belfast, Dr Lindsay Broadbent, says if it is true, it does change the timeline for transmission across Europe, but she advises treating the discovery with caution. "The type of test used to diagnose Covid-19 is an incredibly sensitive test, and contamination can occur very easily." Why would such a discovery be important, if it is true? Dr Broadbent says it doesnt change our current situation, but it would change the accepted timeline of the virus quite drastically. Back in January, "we thought we needed to have contact with someone that had been to a severely affected area, such as Wuhan, and this would change that," because Mr Hamman had not been to China, or indeed travelled abroad for months. "It may also affect how many people within the community have been infected. We know that an awful lot of these people are asymptomatic...and may never have been tested, or requested a test. So, it might mean a lot more people have had this virus than we think." Why is that so important? Well, for one, it changes what we perceive as the death rate from the disease. If many more people had the illness than we thought, and the number of deaths that are recorded stays the same, then the proportion of deaths from Covid-19 shrinks. It also raises questions about immunity in those who have contracted and recovered from the virus. But its not yet clear how long that immunity lasts, according to Dr Broadbent: "There is some good evidence starting to emerge that we will be immune for certainly a short time at least. Whether that lasts several months to a year, we dont know yet. But it does look like the majority of people who are infected do produce antibodies against the virus which is very good news." Other experts have also weighed in on the French study. "It's not impossible that it was an early introduction, but the evidence isn't conclusive by any means," said Jonathan Ball, a professor of molecular virology at Britain's University of Nottingham. Stephen Griffin, an expert at the University of Leeds' Institute of Medical Research, said it was "a potentially important finding," but added: "We must be cautious when interpreting these findings." Rowland Kao, a professor of veterinary epidemiology and data science at Edinburgh University, said that even if it were confirmed, the identification of a positive Covid-19 in December "is not necessarily an indication that the spread of Covid-19 from France started this early". "If confirmed, what this case does highlight is the speed at which an infection starting in a seemingly remote part of the world can quickly seed infections elsewhere," he said.  France is not the only country to re-examine its timeline of the spread of coronavirus. Britain has also been looking for clues as to the source of its outbreak, now seen as the worst in Europe, based on the number of deaths from Covid-19. However, it is important to point out that different countries have different ways of counting fatalities, so comparisons arent always worthwhile. On Tuesday, 5 May, Britains chief scientific adviser, Patrick Vallance, told MPs that genome sequencing suggests that the UK got many of its coronavirus cases from Europe, rather than China. "One of the things that it looks like, very clearly, is that early in March the UK got many, many different imports of virus from many different places," he said. "And those places were particularly from European countries with outbreaks. "And so we see a big influx of cases, probably from Italy and Spain, looking at the genomics of the virus in early March, seeded right the way across the country, and so whether that was people returning from half-term, whether it's business travellers or not we don't know, but a lot of the cases in the UK didn't come from China and didn't come from the places you might have expected. "They actually came from European imports and the high level of travel into the UK around that time." Questions have been raised about a Champions League match with Atletico Madrid in Liverpool in March and whether it increased the spread of coronavirus in the city. Liverpool and the greater region have suffered disproportionately from coronavirus. On 11 March, 3,000 fans travelled from Madrid for the clash with Liverpool, at a time when they were not permitted to watch their own team play at home, as all La Liga matches were ordered to be played behind closed doors, without fans present. Local reports quote public health experts in the city who believe there is a high chance that the surge in cases in the city may have been added to by the Champions League match. Liverpools Mayor Joe Anderson has now asked his public health team to carry out a full investigation to see if there is any connection after a number of deaths were blamed on the match. Scientists in the US are also investigating hidden outbreaks of Covid-19 before the official "first" case was declared on 21 January. According to Alessandro Vespignani, a professor at Northeastern University in Boston, the novel coronavirus was already circulating in major US cities in January. Vespignani and his colleagues used a model to predict the global spread of the virus, based on the infection dynamics of the virus as well as human patterns of movement and interaction. According to research published by the group in March, by the time that China implemented containment measures in Wuhan on 21 January, and the US issued travel restrictions on those travelling to the US ten days later, it was already too late, the virus had spread. Vespignani says the guidelines at the time were only to test people with a travel history to China, so if the virus was circulating in large cities, people could present with symptoms and not be tested, if they hadnt travelled to China but caught it from someone who had. Add to that the fact that January is the height of flu season, and you could get a critical mass of infections going undetected. "If I have an epidemic that starts in early January, I can project a certain trajectory; if I have an epidemic that starts in early March, everything is shifted by two months"But why is this important? According to Professor Vespignani, understanding the timeline of infections can help researchers make predictions about how it will progress. "If I have an epidemic that starts in early January, I can project a certain trajectory; if I have an epidemic that starts in early March, everything is shifted by two months," Vespignani says. "Thats an infinite time for a disease like this one. So you really want to be as sharp as possible, down to the level of a single week, to have the right timeline now to inform what we will see in the next weeks or months." Again, Dr Broadbent advises a degree of caution with the new research from the US, saying that until we have solid data, its just a hypothesis. However, she says the French study does show that it would be a good idea for countries to go back to samples from patients from December, and test them again in a very systematic way for Covid-19. Commenting on the possibility of a new 'patient zero in France in December, the WHO said more information is needed to ascertain the truth in these cases. Maria van Kerkhove, technical lead of WHO's Health Emergencies Program, said: "in this paper, the authors themselves say that it could be a false positive, but assuming it's not, it is possible that this individual may have had Covid-19 in December. "This was about a month before the first case were reported in France. We need more information about this particular case, if this is the case, to find out the different type of history that this individual may have had. It is possible that there could have been a case in France as early as December." She added that currently more than 100 countries and regions have surveillance systems for influenza. "If a sample from January or even December of last year is tested, it may turn out to be positive for Covid-19 and we need to understand how and why this is possible." Meanwhile, Michael Ryan, Executive Director of WHO Health Emergencies Program, added that researchers around the world need to conduct more examinations to find similar cases. | ||||
| 2:47 PM 5/8/2020 - Review of Covid-19 data: New cases by countries | Michael Novakhov - SharedNewsLinks In Brief | ||||
https://tweetsandnews.blogspot.com/2020/05/247-pm-582020-review-of-covid-19-data.html
 Russian spies used French Alps 'as a base camp for covert operations' https://mol.im/a/7765673 via
@MailOnline_______________________________________________________________________________________________
I reviewed the graphs at this page: New cases of covid-19 by countries and regions - Google Search My impressions are that they can be divided in the three patterns of waves. 1. Preliminary: China, South Korea, etc. which appears to be more of the out-layer. I have my ideas why it is so but will let you to do your guessing. 2. Primary wave: most of the Western Europe: Germany, France, Italy, Spain, and the U.S. The number of the new cases appears to rise by the mid-March, the Ides of March, and to peak at approximately the early April, around the April 1, the Fools Day. 3. Secondary or late wave: Russia, Mexico, etc. UK pattern looks more like in between the primary and secondary waves, with the intensity unabating, so far. It is possible that the intentional deliberate introduction and spread of infection continues there, for certain reasons. These patterns have to be studied further. By now it is practically indisputable, that the Pandemic started in October of 2019. The origins of the pathogen, designated as the Sars-Cov-2 remain unclear, and the lab manipulation explanation appears more plausible to me than the "zoonotic jump". Let the specialists work on it. My idea regarding emergence remains the same: Munich Oktoberfest. The details have to be researched. In this type of the investigation the Medical part and the Criminological - Intelligence work part appear to be inseparable and the closely knit parts of the same package. The Preliminary Asian wave was probably introduced first as the cover and to mislead the management of the Pandemic and its investigations, and it might be somewhat different from the main Primary European wave. Michael Novakhov 2:47 PM 5/8/2020 _____________________________________________________________________  » mikenov on Twitter: russian gru spies in wuhan - Google Search google.com/search?q=russi 08/05/20 14:07 from TWEETS BY MIKENOV from mikenova (1 sites) _____________________________________________________________________________ Michael Novakhov - SharedNewsLinks | InBrief | - Mike Nova's Shared NewsLinks Review In 250 Brief Posts -
» mikenov on Twitter: M.N.: But not 100% definitely; lab manipulations cannot be ruled out! - As most (but not all) pathogens capable of causing epidemic at a pandemic scale, SARS-CoV-2 is in all likelihood of zoonotic origin. - sciencedirect.com/science/
08/05/20 14:14 from TWEETS BY MIKENOV from mikenova (1 sites) M.N.: But not 100% definitely; lab manipulations cannot be ruled out! - As most (but not all) pathogens capable of causing epidemic at a pandemic scale, SARS-CoV-2 is in all likelihood of zoonotic origin. - sciencedirect.com/science/arti...
» mikenov on Twitter: russian gru spies in wuhan - Google Search google.com/search?q=russi
08/05/20 14:07 from TWEETS BY MIKENOV from mikenova (1 sites) russian gru spies in wuhan - Google Search google.com/search?q=russi Posted by mikenov on Friday, May 8th, 2020 6:07pm mikenov on Twitter
» mikenov on Twitter: Russian spies used French Alps 'as a base camp for covert operations' mol.im/a/7765673 via @MailOnline
08/05/20 14:04 from TWEETS BY MIKENOV from mikenova (1 sites) Russian spies used French Alps 'as a base camp for covert operations' mol.im/a/7765673 via @MailOnline Posted by mikenov on Friday, May 8th, 2020 6:04pm mikenov on Twitter
» mikenov on Twitter: "Russia stands by China and tells US it must deliver proof over virus allegations" cnbc.com/2020/05/06/rus
08/05/20 13:58 from TWEETS BY MIKENOV from mikenova (1 sites) "Russia stands by China and tells US it must deliver proof over virus allegations" cnbc.com/2020/05/06/rus Posted by mikenov on Friday, May 8th, 2020 5:58pm mikenov on Twitter
» mikenov on Twitter: China, which has reported more than 81,000 cases and more than 3,300 deaths, says no new cases are originating at home. It remains wary of travelers returning from abroad. japantimes.co.jp/news/2020/03/3
08/05/20 13:57 from TWEETS BY MIKENOV from mikenova (1 sites) China, which has reported more than 81,000 cases and more than 3,300 deaths, says no new cases are originating at home. It remains wary of travelers returning from abroad. japantimes.co.jp/news/2020/03/3 Posted by mikenov on Friday, May...
» U.S. spies unclear on COVID-19 spread in China, North Korea and Russia
08/05/20 13:49 from Mike Nova's Shared Newslinks Michael_Novakhov shared this story from Japan Times latest articles. WASHINGTON As U.S. spy agencies seek to assemble a precise picture of the worlds coronavirus outbreaks, they are finding serious gaps in their ability to assess the ...
» mikenov on Twitter: U.S. spies unclear on COVID-19 spread in China, North Korea and Russia | The Japan Times japantimes.co.jp/news/2020/03/3
08/05/20 13:49 from TWEETS BY MIKENOV from mikenova (1 sites) U.S. spies unclear on COVID-19 spread in China, North Korea and Russia | The Japan Times japantimes.co.jp/news/2020/03/3 Posted by mikenov on Friday, May 8th, 2020 5:49pm mikenov on Twitter
» mikenov on Twitter: Italy was engaged in a war of words with Russia on Friday over allegations Moscow hid spies among doctors it had sent to the country's coronavirus epicentre near Milan. a.msn.com/01/en-us/BB128
08/05/20 13:47 from TWEETS BY MIKENOV from mikenova (1 sites) Italy was engaged in a war of words with Russia on Friday over allegations Moscow hid spies among doctors it had sent to the country's coronavirus epicentre near Milan. a.msn.com/01/en-us/BB128 Posted by mikenov on Friday, May 8th, 2020...
» mikenov on Twitter: Italy and Russia spar over alleged coronavirus spies a.msn.com/01/en-us/BB128
08/05/20 13:47 from TWEETS BY MIKENOV from mikenova (1 sites) Italy and Russia spar over alleged coronavirus spies a.msn.com/01/en-us/BB128 Posted by mikenov on Friday, May 8th, 2020 5:47pm mikenov on Twitter
» mikenov on Twitter: all Russian citizens who had expressed a wish to return home had done so, and no further repatriation flights were planned. reuters.com/article/us-chi
08/05/20 13:45 from TWEETS BY MIKENOV from mikenova (1 sites) all Russian citizens who had expressed a wish to return home had done so, and no further repatriation flights were planned. reuters.com/article/us-chi Posted by mikenov on Friday, May 8th, 2020 5:45pm mikenov on Twitter
» mikenov on Twitter: Russians start two-week virus quarantine after return from Wuhan - Reuters reuters.com/article/us-chi
08/05/20 13:45 from TWEETS BY MIKENOV from mikenova (1 sites) Russians start two-week virus quarantine after return from Wuhan - Reuters reuters.com/article/us-chi Posted by mikenov on Friday, May 8th, 2020 5:45pm mikenov on Twitter
» mikenov on Twitter: Russians start two-week virus quarantine after return from Wuhan reut.rs/380Tdhp
08/05/20 13:43 from TWEETS BY MIKENOV from mikenova (1 sites) Russians start two-week virus quarantine after return from Wuhan reut.rs/380Tdhp Posted by mikenov on Friday, May 8th, 2020 5:43pm mikenov on Twitter
» mikenov on Twitter: The main exception to this pattern is China, the source of the initial outbreak, where only a fraction of the global diversity is present (Fig. 2d). sciencedirect.com/science/articl!
08/05/20 13:40 from TWEETS BY MIKENOV from mikenova (1 sites) The main exception to this pattern is China, the source of the initial outbreak, where only a fraction of the global diversity is present (Fig. 2d). sciencedirect.com/science/articl ! Posted by mikenov on Friday, May 8th, 2020 5:40pm mi...
» mikenov on Twitter: The genomic diversity of the global SARS-CoV-2 population being recapitulated in multiple countries points to extensive worldwide transmission of COVID-19, likely from extremely early on in the pandemic. sciencedirect.com/science/artic
08/05/20 13:39 from TWEETS BY MIKENOV from mikenova (1 sites) The genomic diversity of the global SARS-CoV-2 population being recapitulated in multiple countries points to extensive worldwide transmission of COVID-19, likely from extremely early on in the pandemic. sciencedirect.com/science/articl...
» mikenov on Twitter: This genetic diversity of SARS-CoV-2 populations circulating in different countries points to each of these local epidemics having been seeded by a large number of independent introductions of the virus. sciencedirect.com/science/artic
08/05/20 13:39 from TWEETS BY MIKENOV from mikenova (1 sites) This genetic diversity of SARS-CoV-2 populations circulating in different countries points to each of these local epidemics having been seeded by a large number of independent introductions of the virus. sciencedirect.com/science/articl...
» mikenov on Twitter: results add to a growing body of evidence that SARS-CoV-2 viruses share a common ancestor from late 2019, jpost.com/health-science
08/05/20 13:35 from TWEETS BY MIKENOV from mikenova (1 sites) results add to a growing body of evidence that SARS-CoV-2 viruses share a common ancestor from late 2019, jpost.com/health-science Posted by mikenov on Friday, May 8th, 2020 5:35pm mikenov on Twitter
» mikenov on Twitter: "So far, we cannot say whether SARS-CoV-2 is becoming more or less lethal and contagious." jpost.com/health-science
08/05/20 13:33 from TWEETS BY MIKENOV from mikenova (1 sites) "So far, we cannot say whether SARS-CoV-2 is becoming more or less lethal and contagious." jpost.com/health-science Posted by mikenov on Friday, May 8th, 2020 5:33pm mikenov on Twitter
» mikenov on Twitter: Coronavirus may have spread to humans as early as October 2019 - study - The Jerusalem Post jpost.com/health-science
08/05/20 13:32 from TWEETS BY MIKENOV from mikenova (1 sites) Coronavirus may have spread to humans as early as October 2019 - study - The Jerusalem Post jpost.com/health-science Posted by mikenov on Friday, May 8th, 2020 5:32pm mikenov on Twitter
» mikenov on Twitter: a large proportion of the global genetic diversity of the virus causing COVID-19 was found in all of the hardest-hit countries. jpost.com/health-science
08/05/20 13:32 from TWEETS BY MIKENOV from mikenova (1 sites) a large proportion of the global genetic diversity of the virus causing COVID-19 was found in all of the hardest-hit countries. jpost.com/health-science Posted by mikenov on Friday, May 8th, 2020 5:32pm mikenov on Twitter
» covid-19 in uk - Google Search
08/05/20 13:19 from Mike Nova's Shared Newslinks Michael_Novakhov shared this story .
» Study: covid-19 Pandemic started in October - Google Search
08/05/20 13:18 from Mike Nova's Shared Newslinks Michael_Novakhov shared this story . Search Results Web results Covid-19 pandemic may have started in October, says UK ... <a href="http://www.telegraph.co.uk" rel="nofollow">www.telegraph.co.uk</a> news 2020/05/08 covid-19-... <a href="http://www.telegraph.co.uk" rel="nofollow">w...
» Francois Balloux - journal Infection, Genetics and Evolution. - Google Search
08/05/20 13:18 from Mike Nova's Shared Newslinks Michael_Novakhov shared this story . Search Results Scholarly articles for Francois Balloux - journal Infection, Genetics and Evolution. The estimation of population differentiation with - Balloux - Cited by 1333 Genetic variation, i...
» Emergence of genomic diversity and recurrent mutations in SARS-CoV-2 - ScienceDirect
08/05/20 13:16 from Mike Nova's Shared Newslinks Michael_Novakhov shared this story . Infection, Genetics and Evolution Available online 5 May 2020, 104351 In Press, Journal Pre-proof What are Journal Pre-proof articles? Emergence of genomic diversity and recurrent mutations in SARS-Co...
» mikenov on Twitter: Emergence of genomic diversity and recurrent mutations in SARS-CoV-2 - ScienceDirect sciencedirect.com/science/articl
08/05/20 13:15 from TWEETS BY MIKENOV from mikenova (1 sites) Emergence of genomic diversity and recurrent mutations in SARS-CoV-2 - ScienceDirect sciencedirect.com/science/articl Posted by mikenov on Friday, May 8th, 2020 5:15pm mikenov on Twitter
» Coronavirus may have spread to humans as early as October 2019 - study
08/05/20 13:13 from Mike Nova's Shared Newslinks Michael_Novakhov shared this story . A genetic study of samples from more than 7,500 people infected with COVID-19 suggests the new coronavirus spread quickly around the world after it emerged in China sometime between October and Decemb...
» mikenov on Twitter: "Phylogenetic estimates support that the COVID-2 pandemic started sometime around Oct. 6, 2019 to Dec. 11, 2019, which corresponds to the time of the host jump into humans." jpost.com/health-science
08/05/20 13:12 from TWEETS BY MIKENOV from mikenova (1 sites) "Phylogenetic estimates support that the COVID-2 pandemic started sometime around Oct. 6, 2019 to Dec. 11, 2019, which corresponds to the time of the host jump into humans." jpost.com/health-science Posted by mikenov on Friday, May 8th,...
» mikenov on Twitter: Coronavirus may have spread to humans as early as October 2019 - study jpost.com/health-science
08/05/20 13:11 from TWEETS BY MIKENOV from mikenova (1 sites) Coronavirus may have spread to humans as early as October 2019 - study jpost.com/health-science Posted by mikenov on Friday, May 8th, 2020 5:11pm mikenov on Twitter
» mikenov on Twitter: Study: covid-19 Pandemic started in October - Google Search google.com/search?q=Study
08/05/20 13:10 from TWEETS BY MIKENOV from mikenova (1 sites) Study: covid-19 Pandemic started in October - Google Search google.com/search?q=Study Posted by mikenov on Friday, May 8th, 2020 5:10pm mikenov on Twitter
» mikenov on Twitter: The findings, which are based on analysis of more than 7,000 genome sequence assemblies collected from around the world since January, will be published in an upcoming edition of Infection Genetics and Evolution, a scientific journal.
08/05/20 13:08 from TWEETS BY MIKENOV from mikenova (1 sites) The findings, which are based on analysis of more than 7,000 genome sequence assemblies collected from around the world since January, will be published in an upcoming edition of Infection Genetics and Evolution, a scientific journal. te...
» mikenov on Twitter: The Covid-19 pandemic may have started as early as October, according to a new joint study of its genetic make-up by researchers at University College London and the University of Reunion Island. telegraph.co.uk/news/2020/05/0
08/05/20 13:07 from TWEETS BY MIKENOV from mikenova (1 sites) The Covid-19 pandemic may have started as early as October, according to a new joint study of its genetic make-up by researchers at University College London and the University of Reunion Island. telegraph.co.uk/news/2020/05/0 Posted by...
» mikenov on Twitter: Covid-19 pandemic may have started in October, says UK-French study telegraph.co.uk/news/2020/05/0
08/05/20 13:07 from TWEETS BY MIKENOV from mikenova (1 sites) Covid-19 pandemic may have started in October, says UK-French study telegraph.co.uk/news/2020/05/0 Posted by mikenov on Friday, May 8th, 2020 5:07pm mikenov on Twitter
» mikenov on Twitter: Jews Are The Genetic Brothers Of Palestinians, Syrians, And Lebanese sciencedaily.com/releases/2000/
08/05/20 13:02 from TWEETS BY MIKENOV from mikenova (1 sites) Jews Are The Genetic Brothers Of Palestinians, Syrians, And Lebanese sciencedaily.com/releases/2000/ Posted by mikenov on Friday, May 8th, 2020 5:02pm mikenov on Twitter
» mikenov on Twitter: Britain now has Europe's second-highest COVID-19 death toll @AJENews aje.io/qkv8f
08/05/20 12:58 from TWEETS BY MIKENOV from mikenova (1 sites) Britain now has Europe's second-highest COVID-19 death toll @AJENews aje.io/qkv8f Posted by mikenov on Friday, May 8th, 2020 4:58pm mikenov on Twitter
» mikenov on Twitter: ONS weekly COVID-19 deaths E&W - COVID-19 pandemic in the United Kingdom - Wikipedia en.wikipedia.org/wiki/COVID-19_
08/05/20 12:56 from TWEETS BY MIKENOV from mikenova (1 sites) ONS weekly COVID-19 deaths E&W - COVID-19 pandemic in the United Kingdom - Wikipedia en.wikipedia.org/wiki/COVID-19_ Posted by mikenov on Friday, May 8th, 2020 4:56pm mikenov on Twitter
» mikenov on Twitter: Statistics from the ONS published on 1 May 2020 showed that the death rate from the disease had until then been "six times higher among those living in major cities than in rural areas" en.wikipedia.org/wiki/COVID-19_
08/05/20 12:53 from TWEETS BY MIKENOV from mikenova (1 sites) Statistics from the ONS published on 1 May 2020 showed that the death rate from the disease had until then been "six times higher among those living in major cities than in rural areas" en.wikipedia.org/wiki/COVID-19_ Posted by mikenov ...
» mikenov on Twitter: Transmission within the UK was first documented on 28 February, - COVID-19 pandemic in the United Kingdom - Wikipedia en.wikipedia.org/wiki/COVID-19_
08/05/20 12:32 from TWEETS BY MIKENOV from mikenova (1 sites) Transmission within the UK was first documented on 28 February, - COVID-19 pandemic in the United Kingdom - Wikipedia en.wikipedia.org/wiki/COVID-19_ Posted by mikenov on Friday, May 8th, 2020 4:32pm mikenov on Twitter
» mikenov on Twitter: There is large regional variation in the outbreak's severity.COVID-19 pandemic in the United Kingdom - Wikipedia en.wikipedia.org/wiki/COVID-19_
08/05/20 12:31 from TWEETS BY MIKENOV from mikenova (1 sites) There is large regional variation in the outbreak's severity. COVID-19 pandemic in the United Kingdom - Wikipedia en.wikipedia.org/wiki/COVID-19_ Posted by mikenov on Friday, May 8th, 2020 4:31pm mikenov on Twitter
» mikenov on Twitter: The outbreak in London has the highest number and highest rate of infections.[13] England and Wales are the UK countries with the highest recorded death rate per capita, while Northern Ireland has the lowest recorded death rate.[ en.wi
08/05/20 12:30 from TWEETS BY MIKENOV from mikenova (1 sites) The outbreak in London has the highest number and highest rate of infections.[13] England and Wales are the UK countries with the highest recorded death rate per capita, while Northern Ireland has the lowest recorded death rate.[ en.wiki...
» mikenov on Twitter: COVID-19 pandemic in the United Kingdom - Wikipedia en.wikipedia.org/wiki/COVID-19_
08/05/20 12:30 from TWEETS BY MIKENOV from mikenova (1 sites) COVID-19 pandemic in the United Kingdom - Wikipedia en.wikipedia.org/wiki/COVID-19_ Posted by mikenov on Friday, May 8th, 2020 4:30pm mikenov on Twitter | ||||
| U.S. spies unclear on COVID-19 spread in China, North Korea and Russia | ||||
WASHINGTON As U.S. spy agencies seek to assemble a precise picture of the worlds coronavirus outbreaks, they are finding serious gaps in their ability to assess the situation in China, Russia and North Korea, according to five U.S. government sources familiar with the intelligence reporting.
The agencies also have limited insight into the full impact of the pandemic in Iran, although information on infections and deaths among the ruling class and public is becoming more available on official and social media, two sources said. The four countries are known by U.S. spy agencies as hard targets because of the heavy state controls on information and the difficulty, even in normal times, of collecting intelligence from within their closed leadership circles. An accurate assessment of those countries outbreaks would aid U.S. and international efforts to limit the human and economic tolls from COVID-19, the disease caused by the coronavirus, experts say. The agencies are not just looking for accurate numbers, but also for any signs of the political ramifications of how the crisis is being handled. We want to have as close an accurate, real-time understanding of where the global hotspots are and where they are evolving, said Jeremy Konyndyk, an expert at the Center for Global Development thinktank, who led the Office of U.S. Foreign Disaster Assistance from 2013 to 2017, including the U.S. response to the Ebola outbreak. The world is not going to get rid of this thing until we get rid of it everywhere. U.S. intelligence agencies first began reporting on the coronavirus in January and provided early warnings to lawmakers on the outbreak in China, where it originated in the city of Wuhan late last year, said the sources, who asked not to be named in order to speak freely about intelligence matters. The pandemic has grown to nearly 740,000 cases in some 200 countries and territories, Reuters figures show, with the United States now reporting the most cases at more than 152,000. The Office of the Director of National Intelligence, which oversees the 17 U.S. intelligence agencies, declined to comment. North Korea claims to have not had a single case even though it borders China, but has asked international aid agencies for supplies like masks and testing kits. One U.S. source said, we dont know anything about the scale of the problem in the hermetic country. Its a nuclear-armed country where things that could destabilize the government would be of great interest to the United States, said Konyndyk, who also led the U.S. response to the humanitarian crisis in Syria. Russian authorities are considering a nationwide lockdown after recording the biggest one-day rise in coronavirus cases for the sixth day in a row, for a total of 1,836 cases and nine deaths. Knowing the full extent of Russias coronavirus spread could be critical as it shares borders with 14 other countries and is a hub of trade and travel. U.S. Secretary of State Mike Pompeo alluded last week to the dearth of accurate information on Russia and Iran, and accused China of a disinformation campaign, which Beijing denies. China, which has reported more than 81,000 cases and more than 3,300 deaths, says no new cases are originating at home. It remains wary of travelers returning from abroad. The U.S. view of the Chinese claim of no new domestic cases is that some of it may be true, according to one source. U.S. agencies remain skeptical that the Chinese have the virus under control, the source said. Konyndyk said while Beijing concealed the severity of the initial outbreak, it does not appear to be doctoring numbers now, however. China seems to be the most successful country in terms of taking very large-scale growth and rapidly extinguishing it, he said. If their case numbers are real, its really important to understand their approach and adapt it.  | ||||
| covid-19 in uk - Google Search | ||||
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| Study: covid-19 Pandemic started in October - Google Search | ||||
Search ResultsWeb resultsCovid-19 pandemic may have started in October, says UK ...
www.telegraph.co.uk news 2020/05/08 covid-19-...
<a href="http://www.telegraph.co.uk" rel="nofollow">www.telegraph.co.uk</a> news 2020/05/08 covid-19-...
3 hours ago - Joint study 'winds back the clock' of virus genetics and dates initial outbreak as early as October.
Coronavirus may have jumped to humans as early as October ...
www.scmp.com News China Science
<a href="http://www.scmp.com" rel="nofollow">www.scmp.com</a> News China Science
2 days ago - The. Covid-19 pandemic. might have started as early as October, according to the latest research into the genetic make-up of the coronavirus.
Coronavirus research: First cases in October? 200 different ...
www.clickondetroit.com good-health 2020/05/06
<a href="http://www.clickondetroit.com" rel="nofollow">www.clickondetroit.com</a> good-health 2020/05/06
2 days ago - There are countless studies into the coronavirus (COVID-19) going on ... of the virus first began, hundreds of mutations helping COVID-19 ...
New coronavirus spread swiftly around world from late 2019 ...
www.reuters.com us-health-coronavirus-evolution n...
<a href="http://www.reuters.com" rel="nofollow">www.reuters.com</a> us-health-coronavirus-evolution n...
2 days ago - A genetic study of samples from more than 7500 people infected with COVID-19 suggests the new coronavirus spread quickly around the ... support that the COVID-2 pandemic started sometime around Oct. 6, 2019 to Dec.
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| Francois Balloux - journal Infection, Genetics and Evolution. - Google Search | ||||
Search Results
Web resultsEmergence of genomic diversity and recurrent mutations in ...
www.sciencedirect.com science article pii
<a href="http://www.sciencedirect.com" rel="nofollow">www.sciencedirect.com</a> science article pii
Infection, Genetics and Evolution. Available online 5 May 2020, 104351. In Press, Journal Pre-proof What are Journal Pre-proof articles? Infection, Genetics and ...
by L van Dorp - 2020
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| Emergence of genomic diversity and recurrent mutations in SARS-CoV-2 - ScienceDirect | ||||
Emergence of genomic diversity and recurrent mutations in SARS-CoV-2Highlights
Abstract
SARS-CoV-2 is a SARS-like coronavirus of likely zoonotic origin first identified in December 2019 in Wuhan, the capital of China's Hubei province. The virus has since spread globally, resulting in the currently ongoing COVID-19 pandemic. The first whole genome sequence was published on January 52,020, and thousands of genomes have been sequenced since this date. This resource allows unprecedented insights into the past demography of SARS-CoV-2 but also monitoring of how the virus is adapting to its novel human host, providing information to direct drug and vaccine design. We curated a dataset of 7666 public genome assemblies and analysed the emergence of genomic diversity over time. Our results are in line with previous estimates and point to all sequences sharing a common ancestor towards the end of 2019, supporting this as the period when SARS-CoV-2 jumped into its human host. Due to extensive transmission, the genetic diversity of the virus in several countries recapitulates a large fraction of its worldwide genetic diversity. We identify regions of the SARS-CoV-2 genome that have remained largely invariant to date, and others that have already accumulated diversity. By focusing on mutations which have emerged independently multiple times (homoplasies), we identify 198 filtered recurrent mutations in the SARS-CoV-2 genome. Nearly 80% of the recurrent mutations produced non-synonymous changes at the protein level, suggesting possible ongoing adaptation of SARS-CoV-2. Three sites in Orf1ab in the regions encoding Nsp6, Nsp11, Nsp13, and one in the Spike protein are characterised by a particularly large number of recurrent mutations (>15 events) which may signpost convergent evolution and are of particular interest in the context of adaptation of SARS-CoV-2 to the human host. We additionally provide an interactive user-friendly web-application to query the alignment of the 7666 SARS-CoV-2 genomes.
Keywords
Betacoronaviridae
Homoplasies
Mutation
Phylogenetics
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| Coronavirus may have spread to humans as early as October 2019 - study | ||||
A genetic
study
of samples
from
more than 7,500 people infected with COVID-19 suggests the
new coronavirus spread
quickly
around
the
world
after it emerged in China sometime between October and December last year, scientists said on Wednesday.
Scientists at University College London's Genetics Institute found almost 200 recurrent genetic mutations of the new coronavirus - SARS-CoV-2 - which the UCL researchers said showed how it is adapting to its human hosts as it spreads."Phylogenetic estimates support that the COVID-2 pandemic started sometime around Oct. 6, 2019 to Dec. 11, 2019, which corresponds to the time of the host jump into humans," the research team, co-led by Francois Balloux, wrote in a study published in the journal Infection, Genetics and Evolution. Balloux said the analysis also found that the virus was and is mutating, as normally happens with viruses, and that a large proportion of the global genetic diversity of the virus causing COVID-19 was found in all of the hardest-hit countries. That suggests SARS-CoV-2 was being transmitted extensively around the world from early on in the epidemic, he said. "All viruses naturally mutate. Mutations in themselves are not a bad thing and there is nothing to suggest SARS-CoV-2 is mutating faster or slower than expected," he said. "So far, we cannot say whether SARS-CoV-2 is becoming more or less lethal and contagious." In a second study also published on Wednesday, scientists at Britain's University of Glasgow who also analyzed SARS-CoV-2 virus samples said their findings showed that previous work suggesting there were two different strains was inaccurate. JUST ONE VIRUS TYPE CIRCULATING A preliminary study by Chinese scientists in March had suggested there may have been two strains of the new coronavirus causing infections there, with more of them more "aggressive" than the other. But, publishing their analysis in the journal Virus Evolution, the Glasgow team said only one type of the virus was circulating. More than 3.71 million people have been reported to be infected by the novel coronavirus globally and 258,186 have died, according to a Reuters tally. Cases have been reported in more than 210 countries and territories since they were first identified in China in December 2019. The genetic studies offer "fascinating" insights into the evolution of the virus, and emphasize that it is "a moving target with an unknown evolutionary destination," said Jonathan Stoye, head of the division of virology at Britain's Francis Crick Institute. "All the evidence is entirely consistent with an origin towards the end of last year, and there's no reason to question that in any way," Stoye said.
A
study
by
French scientists
published earlier this week found a man in France was infected with COVID-19 as early as Dec. 27, nearly a month before authorities there confirmed the first cases.
Balloux's team screened the genomes of more than 7,500 viruses from infected patients around the world. Their results add to a growing body of evidence that SARS-CoV-2 viruses share a common ancestor from late 2019, suggesting this was when the virus jumped from a previous animal host into people.
The UCL researchers also found almost 200 small genetic changes, or mutations, in the
coronavirus
genomes they analyzed - findings Balloux said offered helpful clues for researchers seeking to develop drugs and vaccines.
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| Potent binding of 2019 novel coronavirus spike protein by a SARS coronavirus-specific human monoclonal antibody | ||||
Very recently, a novel coronavirus which was temporarily named 2019 novel coronavirus (2019-nCoV) emerged in Wuhan, China [1Chan JF, Kok KH, Zhu Z, et al. Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan. Emerg Microbes Infect. 2020;9(1):221236. doi: 10.1080/22221751.2020.1719902 [Taylor & Francis Online], [Web of Science ®], [Google Scholar]]. As of 1 February 2020, 2019-nCoV has resulted in a total of 11,821 laboratory-confirmed human infections in China, including 259 deaths, and 132 exported cases in 23 countries outside of China (https://www.who.int/emergencies/diseases/novel-coronavirus-2019/situation-reports). Currently, there is no vaccine or effective antiviral treatment against 2019-nCoV infection.
Based on the phylogenetic analysis (GISAID accession no. EPI_ISL_402124) [2Zhou P, Yang XL, Wang XG, et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020. doi:10.1038/s41586-020-2012-7. [Epub ahead of print] [Crossref], [Google Scholar]], 2019-nCoV belongs to lineage B betacoronavirus and shares high sequence identity with that of bat or human severe acute respiratory syndrome coronavirus-related coronavirus (SARSr-CoV) and bat SARS-like coronavirus (SL-CoV) (Figure 1(a)). In previous studies, a number of potent monoclonal antibodies against SARS coronavirus (SARS-CoV) have been identified [37Zhu Z, Chakraborti S, He Y, et al. Potent cross-reactive neutralization of SARS coronavirus isolates by human monoclonal antibodies. Proc Natl Acad Sci USA. 2007;104(29):1212312128. doi: 10.1073/pnas.0701000104 [Crossref], [Web of Science ®], [Google Scholar]ter Meulen J, Bakker ABH, van den Brink EN, et al. Human monoclonal antibody as prophylaxis for SARS coronavirus infection in ferrets. The Lancet. 2004;363(9427):21392141. doi: 10.1016/S0140-6736(04)16506-9 [Crossref], [Web of Science ®], [Google Scholar]ter Meulen J, Van Den Brink EN, Poon LLM, et al. Human monoclonal antibody combination against SARS coronavirus: synergy and coverage of escape mutants. PLoS Med. 2006;3(7):e237. doi: 10.1371/journal.pmed.0030237 [Crossref], [Web of Science ®], [Google Scholar]Sui J, Li W, Murakami A, et al. Potent neutralization of severe acute respiratory syndrome (SARS) coronavirus by a human mAb to S1 protein that blocks receptor association. Proc Natl Acad Sci USA. 2004;101(8):25362541. doi: 10.1073/pnas.0307140101 [Crossref], [Web of Science ®], [Google Scholar]Traggiai E, Becker S, Subbarao K, et al. An efficient method to make human monoclonal antibodies from memory B cells: potent neutralization of SARS coronavirus. Nat Med. 2004;10(8):871875. doi: 10.1038/nm1080 [Crossref], [Web of Science ®], [Google Scholar]]. These antibodies target the spike protein (S) of SARS-CoV and SL-CoVs, which is a type I transmembrane glycoprotein and mediates the entrance to human respiratory epithelial cells by interacting with cell surface receptor angiotensin-converting enzyme 2 (ACE2) [8Gallagher TM, Buchmeier MJ. Coronavirus spike proteins in viral entry and pathogenesis. Virology. 2001;279(2):371374. doi: 10.1006/viro.2000.0757 [Crossref], [Web of Science ®], [Google Scholar]]. More specifically, the 193 amino acid length (N318-V510) receptor binding domain (RBD) within the S protein is the critical target for neutralizing antibodies [9Wong SK, Li W, Moore MJ, et al. A 193-amino acid fragment of the SARS coronavirus S protein efficiently binds angiotensin-converting enzyme 2. J Biol Chem. 2004;279(5):31973201. doi: 10.1074/jbc.C300520200 [Crossref], [Web of Science ®], [Google Scholar]]. Some of the antibodies recognize different epitopes on RBD; e.g. the SARS-CoV neutralizing antibodies CR3014 and CR3022 bound noncompetitively to the SARS-CoV RBD and neutralized the virus in a synergistic fashion [5ter Meulen J, Van Den Brink EN, Poon LLM, et al. Human monoclonal antibody combination against SARS coronavirus: synergy and coverage of escape mutants. PLoS Med. 2006;3(7):e237. doi: 10.1371/journal.pmed.0030237 [Crossref], [Web of Science ®], [Google Scholar]]. We predicted the conformation of 2019-nCoV RBD as well as its complex structures with several neutralizing antibodies, and found that the modelling results support the interactions between 2019-nCoV RBD and certain SARS-CoV antibodies (Figure 1(b)). This could be due to the relatively high identity (73%) of RBD in 2019-nCoV and SARS-CoV (Figure 1(c)). For instance, residues in RBD of SARS-CoV that make polar interactions with a neutralizing antibody m396 as indicated by the complex crystal structure [10Prabakaran P, Gan J, Feng Y, et al. Structure of severe acute respiratory syndrome coronavirus receptor-binding domain complexed with neutralizing antibody. J Biol Chem. 2006;281(23):1582915836. doi: 10.1074/jbc.M600697200 [Crossref], [Web of Science ®], [Google Scholar]] are invariably conserved in 2019-nCoV RBD (Figure 1(d)). In the structure of SARS-CoV-RBD-m396, R395 in RBD formed a salt bridge with D95 of m396-VL. Concordantly, the electrostatic interaction was also observed in the model of 2019-nCoV-RBD-m396, forming by R408 (RBD) and D95 (m396-VL). This analysis suggests that some SARS-CoV-specific monoclonal antibodies may be effective in neutralizing 2019-nCoV. In contrast, the interactions between antibody F26G19 [11Pak JE, Sharon C, Satkunarajah M, et al. Structural insights into immune recognition of the severe acute respiratory syndrome coronavirus S protein receptor binding domain. J Mol Biol. 2009;388(4):815823. doi: 10.1016/j.jmb.2009.03.042 [Crossref], [Web of Science ®], [Google Scholar]] or 80R [12Hwang WC, Lin Y, Santelli E, et al. Structural basis of neutralization by a human anti-severe acute respiratory syndrome spike protein antibody, 80R. J Biol Chem. 2006;281(45):3461034616. doi: 10.1074/jbc.M603275200 [Crossref], [Web of Science ®], [Google Scholar]] and the RBD in 2019-nCoV decreased significantly due to the lack of salt bridges formed by R426-D56 in SARS-CoV-RBD-F26G19 or D480-R162 in SARS-CoV-RBD-80R, respectively. Furthermore, while most of the 80R-binding residues on the RBD of SARS-CoV are not conserved on RBD of 2019-nCoV (Figure 1(c)), it is unlikely that the antibody 80R could effectively recognize 2019-nCoV. Therefore, it is urgent to experimentally determine the cross-reactivity of anti-SARS-CoV antibodies with 2019-nCoV spike protein, which could have important implications for rapid development of vaccines and therapeutic antibodies against 2019-nCoV. Published online:17 February 2020
Figure 1. (a) Phylogenetic analysis of 2019-nCoV spike glycoprotein from its protein BLAST sequences. The neighbour-joining tree was constructed using MEGA X, tested by bootstrap method of 2000 replicates, and edited by the online tool of iTOL (v5). (b) The simulated model of 2019-nCoV RBD binding to SARS-CoV-RBD-specific antibodies (m396, 80R, and F26G19). (c) Protein sequence alignment of 2019-nCoV and SARS-CoV RBD, showing the predominant residues that contribute to interactions with ACE2 or SARS-CoV-specific antibodies. (d) The comparison of the complex structures of SARS-CoV-RBD and SARS-CoV-RBD-specific antibodies (shown in the first row) and models of 2019-nCoV-RBD and SARS-CoV-RBD-specific antibodies (shown in the second row). (e) Binding of monoclonal antibodies to 2019-nCoV RBD determined by ELISA. (f) Binding profiles of 2019-nCoV RBD to ACE2 and antibodies, and (g) competition of CR3022 and ACE2 with 2019-nCoV RBD measured by BLI in OctetRED96. Binding kinetics was evaluated using a 1:1 Langmuir binding model by ForteBio Data Analysis 7.0 software.
Figure 1. (a) Phylogenetic analysis of 2019-nCoV spike glycoprotein from its protein BLAST sequences. The neighbour-joining tree was constructed using MEGA X, tested by bootstrap method of 2000 replicates, and edited by the online tool of iTOL (v5). (b) The simulated model of 2019-nCoV RBD binding to SARS-CoV-RBD-specific antibodies (m396, 80R, and F26G19). (c) Protein sequence alignment of 2019-nCoV and SARS-CoV RBD, showing the predominant residues that contribute to interactions with ACE2 or SARS-CoV-specific antibodies. (d) The comparison of the complex structures of SARS-CoV-RBD and SARS-CoV-RBD-specific antibodies (shown in the first row) and models of 2019-nCoV-RBD and SARS-CoV-RBD-specific antibodies (shown in the second row). (e) Binding of monoclonal antibodies to 2019-nCoV RBD determined by ELISA. (f) Binding profiles of 2019-nCoV RBD to ACE2 and antibodies, and (g) competition of CR3022 and ACE2 with 2019-nCoV RBD measured by BLI in OctetRED96. Binding kinetics was evaluated using a 1:1 Langmuir binding model by ForteBio Data Analysis 7.0 software.
In this study, we first expressed and purified 2019-nCoV RBD protein. We also predicted the conformations of 2019-nCoV RBD and its complex with the putative receptor, human ACE2. Comparison of the interaction between the complex of ACE2 [13Li F, Li W, Farzan M, et al. Structure of SARS coronavirus spike receptor-binding domain complexed with receptor. Science. 2005;309(5742):18641868. doi: 10.1126/science.1116480 [Crossref], [Web of Science ®], [Google Scholar]] and SARS-CoV RBD and homology model of ACE2 and 2019-nCoV RBD revealed similar binding modes (data not shown). In both complexes, β5β6 loop and β6β7 loop form extensive contact, including at least seven pairs of hydrogen bonds, with the receptor. Notably, R426 on the forth α helix in SARS-CoV RBD builds a salt bridge with E329 and a hydrogen bond with Q325 on ACE2. However, the arginine (R426 in SARS-CoV RBD) to asparagine (N439) mutation in 2019-nCoV RBD abolished the strong polar interactions, which may induce a decrease in the binding affinity between RBD and the receptor. Interestingly, a lysine (K417 in 2019-nCoV RBD) replacement of valine (V404 in SARS-CoV RBD) on β6 formed an extra salt bridge with D30 on ACE2, which may recover the binding ability. These data indicate that the RBD in S protein of 2019-nCoV may bind to ACE2 with a similar affinity as SARS-CoV RBD does. Indeed, we measured the binding of 2019-nCoV RBD to human ACE2 by the biolayer interferometry binding (BLI) assay, and found that 2019-nCoV RBD bound potently to ACE2. The calculated affinity (KD) of 2019-nCoV RBD with human ACE2 was 15.2nM (Figure 1(f)), which is comparable to that of SARS-CoV spike protein with human ACE2 (15nM) [14Walls AC, Xiong X, Park Y-J, et al. Unexpected receptor functional mimicry elucidates activation of coronavirus fusion. Cell. 2019;176(5):10261039.e15. doi: 10.1016/j.cell.2018.12.028 [Crossref], [Web of Science ®], [Google Scholar]]. These results indicate that ACE2 could be the potential receptor for the new coronavirus, and that the expressed 2019-nCoV RBD protein is functional [2Zhou P, Yang XL, Wang XG, et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020. doi:10.1038/s41586-020-2012-7. [Epub ahead of print] [Crossref], [Google Scholar]].Next, we expressed and purified several representative SARS-CoV-specific antibodies which have been reported to target RBD and possess potent neutralizing activities, including m396 [3Zhu Z, Chakraborti S, He Y, et al. Potent cross-reactive neutralization of SARS coronavirus isolates by human monoclonal antibodies. Proc Natl Acad Sci USA. 2007;104(29):1212312128. doi: 10.1073/pnas.0701000104 [Crossref], [Web of Science ®], [Google Scholar]], CR3014 [4ter Meulen J, Bakker ABH, van den Brink EN, et al. Human monoclonal antibody as prophylaxis for SARS coronavirus infection in ferrets. The Lancet. 2004;363(9427):21392141. doi: 10.1016/S0140-6736(04)16506-9 [Crossref], [Web of Science ®], [Google Scholar]], CR3022 [5ter Meulen J, Van Den Brink EN, Poon LLM, et al. Human monoclonal antibody combination against SARS coronavirus: synergy and coverage of escape mutants. PLoS Med. 2006;3(7):e237. doi: 10.1371/journal.pmed.0030237 [Crossref], [Web of Science ®], [Google Scholar]], as well as a MERS-CoV-specific human monoclonal antibody m336 developed by our laboratory [15Ying T, Prabakaran P, Du L, et al. Junctional and allele-specific residues are critical for MERS-CoV neutralization by an exceptionally potent germline-like antibody. Nat Commun. 2015;6:8223. doi: 10.1038/ncomms9223 [Crossref], [Web of Science ®], [Google Scholar]], and measured their binding ability to 2019-nCoV RBD by ELISA (Figure 1(e)). Surprisingly, we found that most of these antibodies did not show evident binding to 2019-nCoV RBD. To confirm this result, we further measured the binding kinetics using BLI. An irrelevant anti-CD40 antibody was used as a negative control. Similarly, the antibody m396, which was predicted to bind 2019-nCoV RBD (Figure 1(d)), only showed slight binding at the highest measured concentration (2.0µM). Further studies are needed to solve the high-resolution structure of 2019-nCoV RBD and understand why it could not be recognized by these antibodies. Notably, one SARS-CoV-specific antibody, CR3022, was found to bind potently with 2019-nCoV RBD as determined by ELISA and BLI (Figure 1(e,f)). It followed a fast-on (kon of 1.84×105Ms1) and slow-off (koff of 1.16×103s1) binding kinetics, resulting in a KD of 6.3nM (Figure 1(f)). This antibody was isolated from blood of a convalescent SARS patient and did not compete with the antibody CR3014 for binding to recombinant S protein [5ter Meulen J, Van Den Brink EN, Poon LLM, et al. Human monoclonal antibody combination against SARS coronavirus: synergy and coverage of escape mutants. PLoS Med. 2006;3(7):e237. doi: 10.1371/journal.pmed.0030237 [Crossref], [Web of Science ®], [Google Scholar]]. To further elucidate the binding epitopes of CR3022, we measured the competition of CR3022 and human ACE2 for the binding to 2019-nCoV RBD. The streptavidin biosensors labelled with biotinylated 2019-nCoV RBD were saturated with human ACE2 in solution, followed by the addition of the test antibodies in the presence of ACE2. As shown in Figure 1(g), the antibody CR3022 did not show any competition with ACE2 for the binding to 2019-nCoV RBD. These results suggest that CR3022, distinct from the other two SARS-CoV antibodies, recognizes an epitope that does not overlap with the ACE2 binding site of 2019-nCoV RBD. The RBD of 2019-nCoV differs largely from the SARS-CoV at the C-terminus residues (Figure 1(c)). Our results implied that such a difference did not result in drastic changes in the capability to engage the ACE2 receptor, but had a critical impact on the cross-reactivity of neutralizing antibodies. Some of the most potent SARS-CoV-specific neutralizing antibodies (e.g. m396, CR3014) that target the receptor binding site of SARS-CoV failed to bind 2019-nCoV spike protein, indicating that it is necessary to develop novel monoclonal antibodies that could bind specifically to 2019-nCoV RBD. Interestingly, it was reported that the antibody CR3022 completely neutralized both the wild-type SARS-CoV and the CR3014 escape viruses at a concentration of 23.5μg/ml, and that no escape variants could be generated with CR3022 [5ter Meulen J, Van Den Brink EN, Poon LLM, et al. Human monoclonal antibody combination against SARS coronavirus: synergy and coverage of escape mutants. PLoS Med. 2006;3(7):e237. doi: 10.1371/journal.pmed.0030237 [Crossref], [Web of Science ®], [Google Scholar]]. Furthermore, the mixture of CR3022 and CR3014 neutralized SARS-CoV in a synergistic fashion by recognizing different epitopes on RBD [5ter Meulen J, Van Den Brink EN, Poon LLM, et al. Human monoclonal antibody combination against SARS coronavirus: synergy and coverage of escape mutants. PLoS Med. 2006;3(7):e237. doi: 10.1371/journal.pmed.0030237 [Crossref], [Web of Science ®], [Google Scholar]]. These results suggest that CR3022 has the potential to be developed as candidate therapeutics, alone or in combination with other neutralizing antibodies, for the prevention and treatment of 2019-nCoV infections. We expect more cross-reactive antibodies against 2019-nCoV and SARS-CoV or other coronaviruses to be identified soon, facilitating the development of effective antiviral therapeutics and vaccines. | ||||
| Spotlight: COVID-19 virus not created in lab, say French experts - Xinhua | ||||
PARIS, April 20 (Xinhua) -- French experts have refuted the claim by their colleague and Nobel Prize-winning scientist Luc Montagnier that the novel coronavirus causing the COVID-19 pandemic has been engineered and contains some genes of HIV-1.
Montagnier last week told the French CNews channel: "There was manipulation around this virus ... the coronavirus of the bat, someone added sequences, in particular of HIV, the virus of AIDS ... It is not natural. It's the work of professionals, of molecular biologists ... A very meticulous work." The French virologist won the Nobel Prize in Medicine in 2008 for his discovery of the human immunodeficiency viruses (HIV). The hypothesis that a virus was created in a laboratory in Wuhan sounded "a conspiracy vision that does not relate to the real science," said Jean-Francois Delfraissy, an immunologist and head of the scientific council that advises the French government on the COVID-19 pandemic, when interviewed by French television BFM TV. "Everyone in the scientific community agrees that COVID-19 is a coronavirus. From time to time there are coronaviruses different from the others, as are SARS and MERS with a pathogenicity which has appeared," he added. Both Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS) are caused by coronaviruses, and the COVID-19 virus is also known as SARS-CoV-2. "The world of viruses is a world in perpetual evolution," said Delfraissy, who is also president of France's National Consultative Ethics Committee for health and life sciences. "I rather think that COVID-19 is a coronavirus which had an animal reservoir and passed into humans for reasons that are not well known yet." For Olivier Schwartz, head of the virus and immunity department of France's Pasteur Institute, studies on the virus's genes show clearly that it was not a virus made by human beings in the laboratory. "Professor Montagnier spreads whimsical theories," he told the French weekly L'Obs, previously known as Le Nouvel Observateur. "Sars-CoV-2, the virus that causes the COVID-19 disease, was not created in the laboratory. We see this by studying the genetic heritage of the virus, which has been sequenced by Chinese teams and then verified in many other laboratories, including the Pasteur Institute, which was the first in Europe to do so," said Schwartz. "This virus is clearly part of the coronavirus family tree. It is close to Sars-CoV-1, with which it has 80 percent homology," he explained. "Above all, the same virus is found in different animals, in particular the pangolin and the bat. And there, the percentage of similarities is greater than 95 percent. So, by drawing up the family tree of this virus, we know that it is derived from viruses that circulate in nature," he said. What Montagnier spreads is "fake news" that started in March with a manuscript posted by an Indian team on a website where scientists share ongoing analyses without waiting for expert verification, added Schwartz. "The Indian team ended up withdrawing their manuscript. My personal opinion is that these Indian researchers were in good faith at the outset in their desire to analyze the genome of the virus, and they realized their error later. But Professor Montagnier has taken up a whimsical theory," he said. Enditem | ||||
| 8:30 AM 5/7/2020 - The new coronavirus spread quickly around the world... sometime between October and December last year, scientists said on Wednesday. | ||||
https://fbinewsreview.blogspot.com/2020/05/830-am-572020-new-coronavirus-spread.html
 New Coronavirus Spread Swiftly Around World From Late 2019, Study Finds - GS New Coronavirus Spread Swiftly Around World From Late 2019, Study Finds - NYT By Reuters May 6, 2020 LONDON A genetic study of samples from more than 7,500 people infected with COVID-19 suggests the new coronavirus spread quickly around the world after it emerged in China (?!) sometime between October and December last year, scientists said on Wednesday. Mike Nova's Shared NewsLinks Review In 250 Brief Posts -
» mikenov on Twitter: Sewage offers coronavirus clues for scientists trying to understand its spread fxn.ws/3bb0P1A #FoxNews
06/05/20 21:30 from TWEETS BY MIKENOV from mikenova (1 sites) Sewage offers coronavirus clues for scientists trying to understand its spread fxn.ws/3bb0P1A #FoxNews Posted by mikenov on Thursday, May 7th, 2020 1:30am mikenov on Twitter
» mikenov on Twitter: Young healthy people dying of strokes linked to COVID-19 | WKRN News 2 wkrn.com/community/heal
06/05/20 21:27 from TWEETS BY MIKENOV from mikenova (1 sites) Young healthy people dying of strokes linked to COVID-19 | WKRN News 2 wkrn.com/community/heal Posted by mikenov on Thursday, May 7th, 2020 1:27am mikenov on Twitter
» mikenov on Twitter: 85% of inmates in St. Gabriel women's prison got coronavirus but most showed no symptoms theadvocate.com/baton_rouge/ne via @theadvocatebr
06/05/20 21:23 from TWEETS BY MIKENOV from mikenova (1 sites) 85% of inmates in St. Gabriel women's prison got coronavirus but most showed no symptoms theadvocate.com/baton_rouge/ne via @theadvocatebr Posted by mikenov on Thursday, May 7th, 2020 1:23am mikenov on Twitter
» mikenov on Twitter: New evidence on French COVID-19 patient suggests virus may not have started in China | Virus was already being transmitted extensively around the globe from early on in the epidemic. tweetsandnews.blogspot.com/2020/05/437-pm
06/05/20 17:14 from TWEETS BY MIKENOV from mikenova (1 sites) New evidence on French COVID-19 patient suggests virus may not have started in China | Virus was already being transmitted extensively around the globe from early on in the epidemic. tweetsandnews.blogspot.com/2020/05/437-pm Posted by m...
» mikenov on Twitter: #Tweets And #News - From #MichaelNovakhov: 4:37 PM 5/6/2020 - #Gesundheit! #Newevidence on Fre... tweetsandnews.blogspot.com/2020/05/437-pm
06/05/20 17:13 from TWEETS BY MIKENOV from mikenova (1 sites) #Tweets And #News - From #MichaelNovakhov: 4:37 PM 5/6/2020 - #Gesundheit! #Newevidence on Fre... tweetsandnews.blogspot.com/2020/05/437-pm Posted by mikenov on Wednesday, May 6th, 2020 9:13pm mikenov on Twitter
» 4:37 PM 5/6/2020 - Gesundheit! New evidence on French COVID-19 patient suggests virus may not have started in China | Virus was already being transmitted extensively around the globe from early on in the epidemic. - Study Suggests Coronavirus Spread Swift
06/05/20 17:11 from Mike Nova's Shared Newslinks Michael_Novakhov shared this story from Tweets And News - From Michael Novakhov. <a href="https://tweetsandnews.blogspot.com/2020/05/437-pm-562020-gesundheit.html" rel="nofollow">https://tweetsandnews.blogspot.com/2020/05/437-pm-562020-gesundheit.html</a> ________________________________________________________________________ The travel...
» mikenov on Twitter: Tweets And News - From Michael Novakhov: 4:37 PM 5/6/2020 - Gesundheit! New evidence on Fre... tweetsandnews.blogspot.com/2020/05/437-pm
06/05/20 16:59 from TWEETS BY MIKENOV from mikenova (1 sites) Tweets And News - From Michael Novakhov: 4:37 PM 5/6/2020 - Gesundheit! New evidence on Fre... tweetsandnews.blogspot.com/2020/05/437-pm Posted by mikenov on Wednesday, May 6th, 2020 8:59pm mikenov on Twitter
» mikenov on Twitter: If Covid existed in November which some reports suggest was the case it is certainly possible that it was here in December. nytimes.com/2020/05/05/wor
06/05/20 16:44 from TWEETS BY MIKENOV from mikenova (1 sites) If Covid existed in November which some reports suggest was the case it is certainly possible that it was here in December. nytimes.com/2020/05/05/wor Posted by mikenov on Wednesday, May 6th, 2020 8:44pm mikenov on Twitter
» mikenov on Twitter: The travelers sneeze in Oktoberfest in Munich, & then bury their dead at homes, all over the World. But the locals call it the Wiesn Flu, a well known annual phenomenon; & they got vaccinated with the new "Quadrivalent Vaccine"
06/05/20 16:31 from TWEETS BY MIKENOV from mikenova (1 sites) The travelers sneeze in Oktoberfest in Munich, & then bury their dead at homes, all over the World. But the locals call it the Wiesn Flu, a well known annual phenomenon; & they got vaccinated with the new "Quadrivalent Vaccine", ...
» mikenov on Twitter: Hidden Outbreaks Spread Through U.S. Cities Far Earlier Than Americans Knew, Estimates Say nytimes.com/2020/04/23/us/
06/05/20 16:11 from TWEETS BY MIKENOV from mikenova (1 sites) Hidden Outbreaks Spread Through U.S. Cities Far Earlier Than Americans Knew, Estimates Say nytimes.com/2020/04/23/us/ Posted by mikenov on Wednesday, May 6th, 2020 8:11pm mikenov on Twitter
» mikenov on Twitter: similar instances in the United States, where officials recently discovered that deaths from the virus had occurred weeks earlier than previously known nytimes.com/2020/05/05/wor
06/05/20 16:10 from TWEETS BY MIKENOV from mikenova (1 sites) similar instances in the United States, where officials recently discovered that deaths from the virus had occurred weeks earlier than previously known nytimes.com/2020/05/05/wor Posted by mikenov on Wednesday, May 6th, 2020 8:10pm mike...
» mikenov on Twitter: told French television this week that she serves customers who come directly from the airport, with their suitcases, she said. nytimes.com/2020/05/05/wor
06/05/20 16:08 from TWEETS BY MIKENOV from mikenova (1 sites) told French television this week that she serves customers who come directly from the airport, with their suitcases, she said. nytimes.com/2020/05/05/wor Posted by mikenov on Wednesday, May 6th, 2020 8:08pm mikenov on Twitter
» mikenov on Twitter: There are many more flights from CDG airport to Germany rather than China, especially from Munich, so it is much more likely that infection came from there. It is the same principle as with other, e.g. Sweden cases: look closer to hom
06/05/20 16:06 from TWEETS BY MIKENOV from mikenova (1 sites) There are many more flights from CDG airport to Germany rather than China, especially from Munich, so it is much more likely that infection came from there. It is the same principle as with other, e.g. Sweden cases: look closer to home, ...
» mikenov on Twitter: Paris CDG Airport (CDG) to Germany - 10 ways to travel - Charles de Gaulle airport in Paris flights to germany - Google Search google.com/search?q=Charl
06/05/20 16:00 from TWEETS BY MIKENOV from mikenova (1 sites) Paris CDG Airport (CDG) to Germany - 10 ways to travel - Charles de Gaulle airport in Paris flights to germany - Google Search google.com/search?q=Charl Posted by mikenov on Wednesday, May 6th, 2020 8:00pm mikenov on Twitter
» mikenov on Twitter: Cheap Flights from Paris to Munich from $59 - Charles de Gaulle airport in Paris flights to germany - Google Search google.com/search?q=Charl
06/05/20 15:59 from TWEETS BY MIKENOV from mikenova (1 sites) Cheap Flights from Paris to Munich from $59 - Charles de Gaulle airport in Paris flights to germany - Google Search google.com/search?q=Charl Posted by mikenov on Wednesday, May 6th, 2020 7:59pm mikenov on Twitter
» mikenov on Twitter: Mr. Hammars wife, Fatiha, who works in a supermarket near Charles de Gaulle airport in Paris nytimes.com/2020/05/05/wor
06/05/20 15:58 from TWEETS BY MIKENOV from mikenova (1 sites) Mr. Hammars wife, Fatiha, who works in a supermarket near Charles de Gaulle airport in Paris nytimes.com/2020/05/05/wor Posted by mikenov on Wednesday, May 6th, 2020 7:58pm mikenov on Twitter
» mikenov on Twitter: the disease was already spreading among the French population at the end of December 2019. nytimes.com/2020/05/05/wor
06/05/20 15:55 from TWEETS BY MIKENOV from mikenova (1 sites) the disease was already spreading among the French population at the end of December 2019. nytimes.com/2020/05/05/wor Posted by mikenov on Wednesday, May 6th, 2020 7:55pm mikenov on Twitter
» mikenov on Twitter: That, in turn, would help explain the rapidly developing catastrophe that has since unfurled in France and Europe. There have been thousands of cases, hospitalizations and deaths, - nytimes.com/2020/05/05/wor
06/05/20 15:54 from TWEETS BY MIKENOV from mikenova (1 sites) That, in turn, would help explain the rapidly developing catastrophe that has since unfurled in France and Europe. There have been thousands of cases, hospitalizations and deaths, - nytimes.com/2020/05/05/wor Posted by mikenov on Wednes...
» mikenov on Twitter: according to a study of the new case that has been peer-reviewed and accepted for formal publication in the International Journal of Antimicrobial Agents. nytimes.com/2020/05/05/wor
06/05/20 15:52 from TWEETS BY MIKENOV from mikenova (1 sites) according to a study of the new case that has been peer-reviewed and accepted for formal publication in the International Journal of Antimicrobial Agents. nytimes.com/2020/05/05/wor Posted by mikenov on Wednesday, May 6th, 2020 7:52pm m...
» mikenov on Twitter: By the time the first serious measures were put in place the French government didnt order a lockdown until March 16 the virus may have already appeared three months earlier nytimes.com/2020/05/05/wor
06/05/20 15:52 from TWEETS BY MIKENOV from mikenova (1 sites) By the time the first serious measures were put in place the French government didnt order a lockdown until March 16 the virus may have already appeared three months earlier nytimes.com/2020/05/05/wor Posted by mikenov on Wednesday...
» mikenov on Twitter: New Report Says Coronavirus May Have Made Early Appearance in France nytimes.com/2020/05/05/wor
06/05/20 15:49 from TWEETS BY MIKENOV from mikenova (1 sites) New Report Says Coronavirus May Have Made Early Appearance in France nytimes.com/2020/05/05/wor Posted by mikenov on Wednesday, May 6th, 2020 7:49pm mikenov on Twitter
» mikenov on Twitter: Moreover, the absence of a link with China and the lack of recent travel suggests that the disease was already spreading among the French population at the end of December 2019. 7news.com.au/lifestyle/heal
06/05/20 15:39 from TWEETS BY MIKENOV from mikenova (1 sites) Moreover, the absence of a link with China and the lack of recent travel suggests that the disease was already spreading among the French population at the end of December 2019. 7news.com.au/lifestyle/heal Posted by mikenov on Wednesd...
» mikenov on Twitter: Identifying the first infected patient is of great epidemiological interest as it changes dramatically our knowledge regarding SARS-COV-2 and its spreading in (France), they wrote. 7news.com.au/lifestyle/heal
06/05/20 15:38 from TWEETS BY MIKENOV from mikenova (1 sites) Identifying the first infected patient is of great epidemiological interest as it changes dramatically our knowledge regarding SARS-COV-2 and its spreading in (France), they wrote. 7news.com.au/lifestyle/heal Posted by mikenov on Wedn...
» mikenov on Twitter: The finding would also show that the virus was already circulating in Europe well before the first known cases were diagnosed in France or hotspot Italy. 7news.com.au/lifestyle/heal
06/05/20 15:36 from TWEETS BY MIKENOV from mikenova (1 sites) The finding would also show that the virus was already circulating in Europe well before the first known cases were diagnosed in France or hotspot Italy. 7news.com.au/lifestyle/heal Posted by mikenov on Wednesday, May 6th, 2020 7:36pm m...
» mikenov on Twitter: New evidence on French COVID-19 patient suggests virus may not have started in China | 7NEWS.com.au 7news.com.au/lifestyle/heal
06/05/20 15:36 from TWEETS BY MIKENOV from mikenova (1 sites) New evidence on French COVID-19 patient suggests virus may not have started in China | 7NEWS.com.au 7news.com.au/lifestyle/heal Posted by mikenov on Wednesday, May 6th, 2020 7:36pm mikenov on Twitter
» New evidence on French COVID-19 patient suggests virus may not have started in China
06/05/20 15:33 from Mike Nova's Shared Newslinks Michael_Novakhov shared this story from 7NEWS.com.au. Theres new evidence that the first case of coronavirus may not have started in China at all. Doctors at a Paris hospital say theyve found evidence that an ill patient admitted in De...
» mikenov on Twitter: New evidence on French COVID-19 patient suggests virus may not have started in China 7news.com.au/lifestyle/heal
06/05/20 15:33 from TWEETS BY MIKENOV from mikenova (1 sites) New evidence on French COVID-19 patient suggests virus may not have started in China 7news.com.au/lifestyle/heal Posted by mikenov on Wednesday, May 6th, 2020 7:33pm mikenov on Twitter
» mikenov on Twitter: Coronavirus: China says it wants transparent investigation into COVID-19 origin but is refusing one wessexfm.com/news/world/309
06/05/20 15:31 from TWEETS BY MIKENOV from mikenova (1 sites) Coronavirus: China says it wants transparent investigation into COVID-19 origin but is refusing one wessexfm.com/news/world/309 Posted by mikenov on Wednesday, May 6th, 2020 7:31pm mikenov on Twitter
» mikenov on Twitter: p.dw.com/p/3bocj?maca=e Coronavirus in Germany: 100 days later
06/05/20 14:05 from TWEETS BY MIKENOV from mikenova (1 sites) p.dw.com/p/3bocj?maca=e Coronavirus in Germany: 100 days later Posted by mikenov on Wednesday, May 6th, 2020 6:05pm mikenov on Twitter
» mikenov on Twitter: growing body of evidence that SARS-CoV-2 viruses share a common ancestor from late 2019, suggesting this was when the virus jumped from a previous animal host into people.nytimes.com/reuters/2020/0
06/05/20 12:56 from TWEETS BY MIKENOV from mikenova (1 sites) growing body of evidence that SARS-CoV-2 viruses share a common ancestor from late 2019, suggesting this was when the virus jumped from a previous animal host into people. nytimes.com/reuters/2020/0 Posted by mikenov on Wednesday, May 6...
» mikenov on Twitter: "So far, we cannot say whether SARS-CoV-2 is becoming more or less lethal and contagious." nytimes.com/reuters/2020/0
06/05/20 12:54 from TWEETS BY MIKENOV from mikenova (1 sites) "So far, we cannot say whether SARS-CoV-2 is becoming more or less lethal and contagious." nytimes.com/reuters/2020/0 Posted by mikenov on Wednesday, May 6th, 2020 4:54pm mikenov on Twitter
» mikenov on Twitter: Virus was already being transmitted extensively around the globe from early on in the epidemic. - Study Suggests Coronavirus Spread Swiftly Around World in Late 2019 - The New York Times nytimes.com/reuters/2020/0
06/05/20 12:53 from TWEETS BY MIKENOV from mikenova (1 sites) Virus was already being transmitted extensively around the globe from early on in the epidemic. - Study Suggests Coronavirus Spread Swiftly Around World in Late 2019 - The New York Times nytimes.com/reuters/2020/0 Posted by mikenov on W...
» mikenov on Twitter: Study Suggests Coronavirus Spread Swiftly Around World in Late 2019 nytimes.com/reuters/2020/0
06/05/20 12:51 from TWEETS BY MIKENOV from mikenova (1 sites) Study Suggests Coronavirus Spread Swiftly Around World in Late 2019 nytimes.com/reuters/2020/0 Posted by mikenov on Wednesday, May 6th, 2020 4:51pm mikenov on Twitter
» mikenov on Twitter: Italy claims to develop first COVID-19 vaccine: Here is the current status of all the potential coronavirus vaccines | The Times of India timesofindia.indiatimes.com/life-style/hea
06/05/20 12:41 from TWEETS BY MIKENOV from mikenova (1 sites) Italy claims to develop first COVID-19 vaccine: Here is the current status of all the potential coronavirus vaccines | The Times of India timesofindia.indiatimes.com/life-style/hea Posted by mikenov on Wednesday, May 6th, 2020 4:41pm mi...
» mikenov on Twitter: BBC News - Coronavirus mutations: Scientists puzzle over impact bbc.co.uk/news/health-52
06/05/20 12:34 from TWEETS BY MIKENOV from mikenova (1 sites) BBC News - Coronavirus mutations: Scientists puzzle over impact bbc.co.uk/news/health-52 Posted by mikenov on Wednesday, May 6th, 2020 4:34pm mikenov on Twitter | ||||
| 4:37 PM 5/6/2020 - Gesundheit! New evidence on French COVID-19 patient suggests virus may not have started in China | Virus was already being transmitted extensively around the globe from early on in the epidemic. - Study Suggests Coronavirus Spread Swiftly Around World in Late 2019 - The New York Times | Italian research suggests the virus arrived in Lombardy between the second half of January and the beginning of February - weeks before the first infections were confirmed on February 20. | ||||
https://tweetsandnews.blogspot.com/2020/05/437-pm-562020-gesundheit.html
________________________________________________________________________ The travelers sneeze at Oktoberfest in Munich and then bury their Covid-19 dead at their homes, all over the World. But the locals call it the Wiesn Flu, a well known annual phenomenon; and they got vaccinated with the new "Quadrivalent Vaccine" starting from 2018. Maybe this explains the puzzle with the low rates of Coronavirus deaths in Germany! Gesundheit! _____________________________________________
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| New evidence on French COVID-19 patient suggests virus may not have started in China | ||||
Theres new evidence that the first case of coronavirus may not have started in China at all.
Doctors at a Paris hospital say theyve found evidence that an ill patient admitted in December was already infected with COVID-19, with no known association or recent travel to China. Watch the video above Speaking to The Latest on Wednesday, Associate Professor Sanjaya Senanayake, an infectious diseases expert at the Australian National University, said the patient had the illness a month before the first case was confirmed in Wuhan. In this particular case, scientists looked at people who (had tested) negative for flu, but they never had an answer for why they had an infection, he said. They found that this particular man had COVID-19 - this was in late December. Theyve questioned him and he had no obvious associations with travel to or from China, or close associations with China. This suggests that COVID-19 might have been around for longer than we think. Wuhan wet marketsThe French case may put paid to the popularly held theory that coronavirus originated in the wet markets of Wuhan.Even the cluster in Wuhan wet market that we all know about, that may not have been the start of the outbreak, Associate Professor Senanayake said. That may have been when the outbreak and the virus announced itself to the world, but it may have been circulating for a little bit longer. COVID-19 might have been around for longer than we think.The finding would also show that the virus was already circulating in Europe well before the first known cases were diagnosed in France or hotspot Italy. COVID-19 was already spreading in France in late December 2019, a month before the official first cases in the country, the team at Groupe Hospitalier Paris Seine in Saint-Denis wrote in a study published Sunday in the International Journal of Antimicrobial Agents. The first official reports of COVID-19 in France were on January 24 of this year, in two patients who had a history of travel to Wuhan, China. But the French team looked at people admitted to the hospital with flu-like illness between December 2 and January 16 who were not ultimately diagnosed with influenza. Trip to AlgeriaThey tested frozen samples from those patients for coronavirus.One sample was taken from a 42-year-old man born in Algeria, who lived in France for many years, and worked as a fishmonger, the team wrote. His last trip was in Algeria during August 2019. More on 7NEWS.com.au The researchers said identifying the first infected patient could change what we know about the origins of the virus. Identifying the first infected patient is of great epidemiological interest as it changes dramatically our knowledge regarding SARS-COV-2 and its spreading in (France), they wrote. Moreover, the absence of a link with China and the lack of recent travel suggests that the disease was already spreading among the French population at the end of December 2019. Europe did not start reporting cases of coronavirus until January. In Italy, the European country hit hardest by the virus, the first two cases were reported on January 31, in two Chinese tourists in Rome. The first known community transmission was recorded at the end of February in Codogno, northern Italy. - with CNN | ||||
| Poor methods weakened FBI investigation of 2001 anthrax attacks, report concludes | Science | ||||
FBIs investigation of the 2001 anthrax letter attacks that killed five people in the United States was marred by weak scientific practices and analytical gaps, a report by Congresss watchdog agency has concluded. The findings, released 19 December, mirror those reached by a similar study conducted in 2011 by the National Academy of Sciences (NAS).
In 2008, FBI concluded that microbiologist Bruce Ivins, who worked for a U.S. Army research laboratory in Maryland, was responsible for the letter attacks. Ivins committed suicide shortly before the FBI released its findings. But the governments case was largely circumstantial and rested in part on genetic analyses of anthrax spores used in the attacks and in Ivinss laboratory. The 2011 NAS review concluded that the science behind the investigation could not rule out the possibility that someone other than Ivins committed the crime. Last weeks study, from the Government Accountability Office (GAO), comes to a similar conclusion. In particular, GAO found that contractors hired by FBI to test and evaluate the anthrax spores relied on poorly designed sampling and statistical methods. [T]he FBI lacked a comprehensive approachor frameworkthat could have ensured standardization of the testing process, the report states. As a result, each of the contractors developed their tests differently, and one contractor did not conduct verification testing, a key step in determining whether a test will meet a user's requirements, such as for sensitivity or accuracy. FBI also failed to conduct research to provide a full understanding of the methods and conditions that give rise to genetic mutations used to differentiate between samples of B. anthracis, the report states. Similarities between the strains used in Ivinss laboratory and in at least four attack letters were a key element in FBIs case, but a failure to understand how the bacteria mutate over time could complicate efforts to compare samples. Several government agencies are now sponsoring research aimed at filling this gap, and FBI has taken steps to improve its scientific practices, the report notes. FBI needed better science and measurement in order to be more conclusive, GAOs chief scientist, Timothy Persons, told The New York Times. It sounds nitpicky, but thats important in building up the scientific evidence for an important case. The GAO report confirms what I have often saidthat the F.B.I.s definitive conclusions about the accuracy of their scientific findings in the Amerithrax case are not, in fact, definitive, Representative Rush Holt (DNJ), who requested the report in 2010, told the Times. (Holt is retiring this month from Congress and in February will become the CEO of AAAS, publisher of ScienceInsider.) GAO was careful to note, however, that it did not review and is not taking a position on the conclusions the FBI reached when it closed its investigation in 2010. | ||||
| Genetic Study Shows COVID-19 Was in France Weeks Before The First Case Was Reported | ||||
China reported its first cases of the new coronavirus in December. But was COVID-19 already silently circulating? To find out scientists are looking for "patient zeros" by tracking the evolution of the virus itself.
This genetic detective work is tracing the family tree of the coronavirus that has killed tens of thousands in its relentless spread across the planet. It could also help find out if the virus was spreading in other countries before the first infections were officially recorded. In France, a cluster of cases was discovered in late January. But a new study published in the International Journal of Antimicrobial Agents has suggested the virus was already in the country a month earlier. A retrospective analysis of samples taken from 14 intensive care patients with influenza-like symptoms at the Avicenne and Jean-Verdier hospitals in Paris found one positive COVID-19 case - a 42-year-old French resident who had not visited China. He was hospitalised on December 27. Olivier Bouchaud, head of the infectious diseases department at Avicenne said at first the virus spreads "quietly in the population, without anyone detecting its presence". So evidence of earlier infections would only confirm what many scientists had suspected, he told AFP. It might also help explain cases like that of Aicha, a 57-year-old medical secretary who was hospitalised in Marseille in mid-January with severe respiratory symptoms. At the time the mysterious outbreak of pneumonia cases in the Chinese city of Wuhan was still seen as a faraway problem. France did not have a single case and the World Health Organization was still weeks away from giving it the name COVID-19. Aicha's husband Jacques, a doctor, said she had "all the clinical signs" of the disease, including loss of taste and smell. But her tests have been inconclusive. Other countries are discovering they may have had earlier infections. In the United States, autopsies performed on suspicious deaths in California have revealed infections before the first official case on January 21. But Samuel Alizon, of the French National Centre for Scientific Research at Montpellier University, has cautioned that it is important to distinguish between isolated cases and the origin of the "epidemic wave". China originsIn China, Wuhan health authorities have spoken of an initial case on December 8.A study published in The Lancet in January said the first patient identified in the city started showing symptoms on December 1. The timeline has been roughly corroborated by research mapping out the genetic evolution of the virus. So far the genomes of more than 15,000 samples of the new coronavirus have been sequenced. As it replicates it produces multiple mutations, although none has been found to change its virulence. Alizon said that about twice a month a mutation happens that stays in the genetic sequence, giving researchers a trail to follow. So "if you compare two viruses, you can count how many mutations separate them," he said. Following the chain we find the "ancestor common to all infections". Using publicly shared genome sequences, Andrew Rambaut of the University of Edinburgh found that the "lack of diversity is indicative of a relatively recent common ancestor for all these viruses". He estimated that this ancestor could have emerged around November 17 last year (with a range of uncertainty between August 27 and December 29). Imperial College London, in collaboration with the WHO, has also traced the virus' family tree, estimating that it appeared in China on December 5 (with a margin of uncertainty between November 6 and December 13). Erik Volz, an epidemiologist at Imperial College, said all of the very earliest genetic sequences of the virus collected in Wuhan in December and January "have almost identical genomes". "And all viruses currently circulating elsewhere in the world are descended from these closely related lineages in Wuhan," he told AFP. But experts do not think of an epidemic as having a single starting point in time, he added: rather, they are seeded "multiple times from multiple points of origin". He said estimates of the dates of these "seeding events" suggests the epidemics in many European and North American cities began in mid-January or early February. 'We will never know'Italian research suggests the virus arrived in Lombardy between the second half of January and the beginning of February - weeks before the first infections were confirmed on February 20.Football players for Inter Milan have said they suffered symptoms of the virus at the beginning of the year. Could they have had it? "We had a week off in December and then we went back to work and I swear that 23 out of 25 players were sick," Belgian Inter Milan striker Romelu Lukaku said in a recent radio interview. The players were not tested for the virus at the time. Even if they took serological tests now and antibodies were found in their blood, it would not confirm when they were infected. "We will never know," said Lukaku. © Agence France-Presse
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