8:38 AM 9/10/2020 - News - coronavirus and the brain
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8:38 AM 9/10/2020 - News - coronavirus and the brain - Google Search google.com/search?q=coron pic.twitter.com/3rRHsFVcGH
Michael Novakhov - SharedNewsLinks℠ | In Brief |
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| Three Stages to COVID-19 Brain Damage, New Review ... coronavirus and the brain: reviews - Google Search google.com/search?q=coron pic.twitter.com/kgEsaCUgME | |||||||
Three Stages to COVID-19 Brain Damage, New Review ... coronavirus and the brain: reviews - Google Search google.com/search?q=coron pic.twitter.com/kgEsaCUgME  | |||||||
| News - coronavirus and the brain - Google Search google.com/search?q=coron pic.twitter.com/3rRHsFVcGH | |||||||
News - coronavirus and the brain - Google Search google.com/search?q=coron pic.twitter.com/3rRHsFVcGH  | |||||||
| 8:09 AM 9/10/2020 - Trump administration intends to end Covid-19 screenings of passengers arriving from overseas - Saved and Shared Stories In 50 Posts | |||||||
8:09 AM 9/10/2020 - Saved and Shared Stories In 50 Posts___________________________________________
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| Neuroinvasion of SARS-CoV-2 in human and mouse brain | bioRxiv | |||||||
AbstractAlthough COVID-19 is considered to be primarily a respiratory disease, SARS-CoV-2 affects multiple organ systems including the central nervous system (CNS). Yet, there is no consensus whether the virus can infect the brain, or what the consequences of CNS infection are. Here, we used three independent approaches to probe the capacity of SARS-CoV-2 to infect the brain. First, using human brain organoids, we observed clear evidence of infection with accompanying metabolic changes in the infected and neighboring neurons. However, no evidence for the type I interferon responses was detected. We demonstrate that neuronal infection can be prevented either by blocking ACE2 with antibodies or by administering cerebrospinal fluid from a COVID-19 patient. Second, using mice overexpressing human ACE2, we demonstrate in vivo that SARS-CoV-2 neuroinvasion, but not respiratory infection, is associated with mortality. Finally, in brain autopsy from patients who died of COVID-19, we detect SARS-CoV-2 in the cortical neurons, and note pathologic features associated with infection with minimal immune cell infiltrates. These results provide evidence for the neuroinvasive capacity of SARS-CoV2, and an unexpected consequence of direct infection of neurons by SARS-CoV-2. | |||||||
| coronavirus and the brain - Google Search | |||||||
How Does Coronavirus Affect the Brain? | Johns Hopkins ...www.hopkinsmedicine.org conditions-and-diseases <a href="http://www.hopkinsmedicine.org" rel="nofollow">www.hopkinsmedicine.org</a> conditions-and-diseases Jun 4, 2020 - Q: In what ways does the coronavirus affect the brain? A: Cases around the world show that patients with COVID-19 can have a variety of ... How the Coronavirus Attacks the Brain - The New York Timeswww.nytimes.com 2020/09/09 health coronavirus-b... <a href="http://www.nytimes.com" rel="nofollow">www.nytimes.com</a> 2020/09/09 health coronavirus-b... 14 hours ago - How the Coronavirus Attacks the Brain. It's not just the lungs the pathogen may enter brain cells, causing symptoms like delirium and confusion ... From 'brain fog' to heart damage, COVID-19's lingering ...www.sciencemag.org news 2020/07 brain-fog-he... <a href="http://www.sciencemag.org" rel="nofollow">www.sciencemag.org</a> news 2020/07 brain-fog-he... Jul 31, 2020 - The list of lingering maladies from COVID-19 is longer and more varied than most doctors could have imagined. Ongoing problems include ... | |||||||
| 7:25 AM 9/10/2020 - Tweets: Sexual harassment in the FBI - the hidden epidemic. What do we really know about it? | |||||||
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| itnnews's YouTube Videos: West Coast Wildfires: San Francisco's Golden Gate Bridge Covered in Dramatic Orange Haze | |||||||
Unprecedented wildfires plunged San Franciscos Bay Bridge into an apocalyptic orange glow, as a cloud of smoke covered much of California. A record 2.3 million acres have been burned this year in the state since the start of the wildfire season. Over 14,000 firefighters are battling fires in California, but blazes have been reported across the the US Pacific Northwest. #CaliforniaFires #Wildfires #SanFrancisco Report by Gianluca Avagnina. Subscribe here: http://bit.ly/ODNsubs Twitter: https://twitter.com/ODN Facebook: https://www.facebook.com/ODN/ If you wish to purchase any of our clips for commercial use, please visit: http://www.itnproductions.co.uk/news/  | |||||||
| How the Coronavirus Attacks the Brain | |||||||
The coronavirus targets the lungs foremost, but also the kidneys, liver and blood vessels. Still, about half of patients report neurological symptoms, including headaches, confusion and delirium, suggesting the virus may also attack the brain. A new study offers the first clear evidence that, in some people, the coronavirus invades brain cells, hijacking them to make copies of itself. The virus also seems to suck up all of the oxygen nearby, starving neighboring cells to death. Its unclear how the virus gets to the brain or how often it sets off this trail of destruction. Infection of the brain is likely to be rare, but some people may be susceptible because of their genetic backgrounds, a high viral load or other reasons. If the brain does become infected, it could have a lethal consequence, said Akiko Iwasaki, an immunologist at Yale University who led the work. The study was posted online on Wednesday and has not yet been vetted by experts for publication. But several researchers said it was careful and elegant, showing in multiple ways that the virus can infect brain cells. Scientists have had to rely on brain imaging and patient symptoms to infer effects on the brain, but we hadnt really seen much evidence that the virus can infect the brain, even though we knew it was a potential possibility, said Dr. Michael Zandi, consultant neurologist at the National Hospital for Neurology and Neurosurgery in Britain. This data just provides a little bit more evidence that it certainly can. Dr. Zandi and his colleagues published research in July showing that some patients with Covid-19, the illness caused by the coronavirus, develop serious neurological complications, including nerve damage. In the new study, Dr. Iwasaki and her colleagues documented brain infection in three ways: in brain tissue from a person who died of Covid-19, in a mouse model and in organoids clusters of brain cells in a lab dish meant to mimic the brains three-dimensional structure. Other pathogens including the Zika virus are known to infect brain cells. Immune cells then flood the damaged sites, trying to cleanse the brain by destroying infected cells. The coronavirus is much stealthier: It exploits the brain cells machinery to multiply, but doesnt destroy them. Instead, it chokes off oxygen to adjacent cells, causing them to wither and die. The researchers didnt find any evidence of an immune response to remedy this problem. Its kind of a silent infection, Dr. Iwasaki said. This virus has a lot of evasion mechanisms. Coronavirus Schools Briefing: Its back to school or is it? These findings are consistent with other observations in organoids infected with the coronavirus, said Alysson Muotri, a neuroscientist at the University of California, San Diego, who has also studied the Zika virus. The coronavirus seems to rapidly decrease the number of synapses, the connections between neurons. Days after infection, and we already see a dramatic reduction in the amount of synapses, Dr. Muotri said. We dont know yet if that is reversible or not. The virus infects a cell via a protein on its surface called ACE2. That protein appears throughout the body and especially in the lungs, explaining why they are favored targets of the virus. Previous studies have suggested, based on a proxy for protein levels, that the brain has very little ACE2 and is likely to be spared. But Dr. Iwasaki and her colleagues looked more closely and found that the virus could indeed enter brain cells using this doorway. Its pretty clear that it is expressed in the neurons and its required for entry, Dr. Iwasaki said. Her team then looked at two sets of mice one with the ACE2 receptor expressed only in the brain, and the other with the receptor only in the lungs. When researchers introduced the virus into these mice, the brain-infected mice rapidly lost weight and died within six days. The lung-infected mice did neither. Despite the caveats attached to mouse studies, the results still suggest that virus infection in the brain may be more lethal than respiratory infection, Dr. Iwasaki said. The virus may get to the brain through the olfactory bulb which regulates smell through the eyes or even from the bloodstream. Its unclear which route the pathogen is taking, and whether it does so often enough to explain the symptoms seen in people. I think this is a case where the scientific data is ahead of the clinical evidence, Dr. Muotri said. Researchers will need to analyze many autopsy samples to estimate how common brain infection is and whether it is present in people with milder disease or in so-called long-haulers, many of whom have a host of neurological symptoms. Forty percent to 60 percent of hospitalized Covid-19 patients experience neurological and psychiatric symptoms, said Dr. Robert Stevens, a neurologist at Johns Hopkins University. But the symptoms may not all stem from the viruss invasion of brain cells. They may be the result of pervasive inflammation throughout the body. For example, inflammation in the lungs can release molecules that make the blood sticky and clog up blood vessels, leading to strokes. Theres no need for the brain cells themselves to be infected for that to occur, Dr. Zandi said. But in some people, he added, it may be low blood oxygen from infected brain cells that leads to strokes: Different groups of patients may be affected in different ways, he said. Its quite possible that youll see a combination of both. Some cognitive symptoms, like brain fog and delirium, might be harder to pick up in patients who are sedated and on ventilators. Doctors should plan to dial down sedatives once a day, if possible, in order to assess Covid-19 patients, Dr. Stevens said. | |||||||
| 12:51 AM 9/10/2020 - Trump Nominated For Nobel Peace Prize | |||||||
12:51 AM 9/10/2020 - Trump Nominated For Nobel Peace Prizehttps://thenewsandtimes.blogspot.com/2020/09/1251-am-9102020-trump-nominated-for.html
Michael Novakhov - SharedNewsLinks
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| Former DNI Dan Coats thinks Putin has Trump blackmail: Woodward book | |||||||
  Dan Coats, the former top intelligence official under President Donald Trump, harbored a "secret belief" that Russian President Vladimir Putin had kompromat on Trump, the veteran journalist Bob Woodward wrote in his book "Rage." The book is set to be released next Tuesday, but CNN obtained an early copy and published excerpts this week. Coats was the director of national intelligence from January 2017 to July 2019. In his book, Woodward wrote that Coats "continued to harbor the secret belief, one that had grown rather than lessened, although unsupported by intelligence proof, that Putin had something on Trump." "How else to explain the president's behavior?" Woodward wrote, according to CNN. "Coats could see no other explanation." Coats and senior staffers in his office "examined the intelligence as carefully as possible," Woodward wrote. But Coats was still uneasy about Trump and Putin's relationship. He "saw how extraordinary it was for the president's top intelligence official to harbor such deep suspicions about the president's relationship with Putin," Woodward wrote. "But he could not shake them." "Rage" is Woodward's second book about the Trump administration; he also wrote the 2018 bestseller "Fear: Trump in the White House." The president has railed against "Rage," calling it fake news and saying Woodward didn't conduct any interviews with him ahead of the book's release. For his second book about the administration, Woodward did 18 extensive interviews with the president from December 5 to July 21, according to CNN. Woodward recorded the interviews with Trump's permission, and CNN obtained copies of some of the tapes. Still, Trump said in a tweet last month that the book was "a FAKE, as always, just as many of the others have been." Coats a former Republican senator from Indiana and other senior national security officials, like former Defense Secretary James Mattis, discussed whether they needed to take "collective action" to speak out against Trump, Woodward wrote, according to CNN. Mattis resigned in late 2018 after Trump decided to pull US troops out of Syria, telling Woodward he decided to leave "when I was basically directed to do something that I thought went beyond stupid to felony stupid." The US intelligence community determined in early 2017 that Russia interfered in the 2016 presidential election to propel Trump to the Oval Office. Coats and other intelligence officials testified to Congress last year that Russia was one of the biggest national security threats facing the US ahead of the 2020 election and that it would continue employing the tactics it used in 2016 and during the 2018 midterm elections. The intelligence community also said last month that both Russia and China were attempting to interfere in this year's election and that Russia wanted Joe Biden, the Democratic nominee, to lose, while China wanted him to win. "We assess that Russia is using a range of measures to primarily denigrate former Vice President Biden and what it sees as an anti-Russia 'establishment,'" William Evanina, the director of the National Counterintelligence and Security Center, said in a statement. "This is consistent with Moscow's public criticism of him when he was Vice President for his role in the Obama Administration's policies on Ukraine and its support for the anti-Putin opposition inside Russia." Trump, meanwhile, has consistently refused to explicitly condemn Russia for its actions. His 2016 campaign derided the CIA after it concluded that year that Russia meddled in the election to help Trump. He also repeatedly criticized and attempted to thwart the FBI's investigation into Russia's interference, describing it as a "hoax" designed to undermine his presidency, even as several high profile figures in his inner circle pleaded guilty to or were convicted of crimes stemming from the probe. In 2018, during a joint press conference with Putin following a bilateral summit in Helsinki, Trump publicly sided with the Russian leader over the US intelligence community, saying, "I don't see any reason why it would be" Russia that meddled in the 2016 election. The president later walked back his comments after facing swift public backlash. John Bolton, Trump's former national security adviser, told Insider in an interview last month that the president's comments during the Helsinki summit were the most shocking and disappointing he'd heard throughout his tenure. "I was sitting in the audience with Chief of Staff John Kelly, and we were both frozen to our chairs," Bolton told Business Insider. "We couldn't believe what we had heard. And we spent a good part of the flight on Air Force One back to Washington trying to explain to the president why he was getting such a negative reaction from the press back in Washington. The president didn't seem to understand that people might be upset that he equated what Putin said with what our intelligence community said." | |||||||
| Former Spy Chief Believes Putin Had Something on Trump - 'He's Dangerous. He's Unfit' | |||||||
Former director of national intelligence Dan Coats could not shake his deep suspicions that Russian President Vladimir Putin had something on President Trump, seeing no other explanation for the presidents behavior, according to Bob Woodwards new book Rage.Coats was the presidents top intelligence official from March 2017 until August 2019. Woodward reports that Coats and his staff examined the intelligence regarding Trumps ties to Russia as carefully as possible and that he still questions the relationship between Trump and Putin despite the apparent absence of intelligence proof. But Coats was still uneasy about the relationship between Trump and Putin. He saw how extraordinary it was for the presidents top intelligence official to harbor such deep suspicions about the presidents relationship with Putin. But he could not shake them. The New York Times Michael Schmidt reported in his new book that former Deputy Attorney General Rod Rosenstein secretly curtailed an FBI counterintelligence probe into Trumps ties to Russia, meaning the full scope of decades of the presidents personal and financial dealings there has never been explored. The explosive Woodward book, which is based in part on 18 interviews that Trump sat for with the veteran journalist, details the tortured tenure of Coats and other officials described by the Washington Post as so-called adults of the Trump orbit including former Defense Secretary James Mattis and former Secretary of State Rex Tillerson. At one point, Mattis went to Washington National Cathedral to pray for the countrys fate under Trumps leadership. He reportedly told Coats, There may come a time when we have to take collective action to speak out against Trump because he is dangerous. Hes unfit. In a later conversation reported by Woodward, Mattis told Coats, The president has no moral compass. Coats reportedly responded, True. To him, a lie is not a lie. Its just what he thinks. He doesnt know the difference between the truth and a lie.
The US intelligence community determined in early 2017 that Russia interfered in the 2016 presidential election to propel Trump to the Oval Office. Coats and other intelligence officials testified to Congress last year that Russia was one of the biggest national security threats facing the US ahead of the 2020 election and that it would continue employing the tactics it used in 2016 and during the 2018 midterm elections. Trump is angered by the release of the Woodward book. The Bob Woodward book will be a FAKE, as always, just as many of the others have been, Trump tweeted on Aug. 14, before the book had come out. This is despite the fact that the president sat for 18 interviews with Woodward.  ON TAPE: Trump Admits To Woodward He 'Downplayed' Coronavirus With American PeoplePresident Trump admitted he knew weeks before the first confirmed US coronavirus death that the virus was dangerous, airborne, highly contagious and "more deadly than even your strenuous flus," and that he repeatedly played it down publicly. "This is deadly stuff," Trump told legendary journalist Bob Woodward on February 7. September 9, 2020 In "2020"  Dan Coats Out As Intelligence Director - Trump Defender Ratcliffe NominatedPresident Trump announced on Twitter today that he will nominate Rep. John Ratcliffe (R-Texas) to replace Dan Coats as director of national intelligence. Coats, one of the reasonable voices left in the Trump cabinet, will leave office on August 15. Coats had rankled Trump more than once with his public July 28, 2019 In "Headlines"  FIRST SECURITY: Trump Pushed CIA To Give Taliban Intelligence To KremlinWhy would the Russian government think it could get away with paying bounties to the Taliban to kill American soldiers? One answer to that question may be the extraordinary response that Moscow received when the Trump administration learned of a precursor to the bounty operation. From mid-2017 and into 2018, July 8, 2020 In "Foreign Affairs" | |||||||
| 6:57 AM 9/9/2020 - Today's Topics: Are California fires premeditated arsons? | |||||||
6:57 AM 9/9/2020 - Today's Topics Are California fires the premeditated arsons? Sexual harassment in FBIThe Union Journal Unhinged Pelosi Spreads Wild Conspiracy Theories About ... House Speaker Nancy Pelosi shared unhinged conspiracy theories about President Donald Trump being blackmailed and controlled by Russian President ... 10 hours ago M.N.: This is the correct assessment, not a "conspiracy theory":House Speaker Nancy Pelosi shared unhinged conspiracy theories about President Donald Trump being blackmailed and controlled by Russian President Vladimir Putin. Pelosi: Trump Is A Putin AccompliceI dont know what Putin has on the president politically, personally or financially, Pelosi said on an appearance with MSNBCs Maria Theresa Kumar. Well find out when we see the presidents tax returns. But I do know that [Putin] has engaged in these kind of activities in other countries in order to discredit democracy, in order to discredit democracy. And that our own president should be an accomplice to that just raises so many questions, Pelosi concluded. ______________________________________________________ | |||||||
| 12:22 PM 9/8/2020 - Tweets by @mikenov | |||||||
 12:22 PM 9/8/2020 - Tweets by @mikenov
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| 12:06 PM 9/8/2020 - The Useful Idiot | |||||||
 12:06 PM 9/8/2020 - The Useful Idiot Michael Novakhov - SharedNewsLinks All Saved Stories - 25 -
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| 11:19 AM 9/8/2020 - Coronavirus and US Military: Coronavirus numbers drop for US military in Japan as Tokyo reports spurt of new infections | |||||||
 11:19 AM 9/8/2020 - Coronavirus and US Military: Coronavirus numbers drop for US military in Japan as Tokyo reports spurt of new infections https://thenewsandtimes.blogspot.com/2020/09/1119-am-982020-coronavirus-and-us.html _________________________________________________________________________ Michael Novakhov - SharedNewsLinks All Saved Stories - 25 - | |||||||
| Is COVID-19 Primarily a Heart and Vascular Diseases? | Infection Control Today | |||||||
Infection preventionists need to be able to articulate to those who feel that the young are safe just because their fatality rate is extremely low, that even in this age group there are major concerns regarding long-term consequences of this virus. Several recent studies have supported the growing hypothesis that coronavirus disease 2019 (COVID-19) is primarily a cardiovascular, and not a pulmonary virus. The narrative that those affected are usually asymptomatic and have very mild or no disease may be false. Many of those who are asymptomatic may actually fall victim to myocarditis, a sinister, stealth-like disease, whose resulting disability may take decades to manifest. Concerns for cardiovascular involvement of SARS-CoV-2 have been present since the early genesis of the pandemic. A research paper from China found that 20% of COVID-19 hospitalized patients developed heart disease and thromboembolic events happened in 31% of those in the ICU. Another from Germany reported ongoing myocardial inflammation in 60% of 100 recently recovered patients with COVID-19. However, cardiovascular disease has been assumed by many to be a manifestation of severe COVID-19; and not from direct infection of the virus but instead from small vessel disease caused by the hypercoagulation of the blood. All of that changed last week with the publication of three reports. The first was from the Penn State team doctor who found that one-third of Penn State athletes who tested positive for COVID-19 had myocarditis. These were young athletes and included both mildly symptomatic and asymptomatic individuals. As a result of these findings, the Big 10 and Pac 12 postponed their football season. Myocarditis does not have specific symptoms and most patients can be asymptomatic. Myocarditis can produce fibrosis of the heart which may present years later with heart failure from dilated cardiomyopathy. However, in 50% of cases the cause of dilated cardiomyopathy is unknown, but there is strong evidence that past viral infections play a role. And myocarditis can occur in children. The second was a study by Perez-Bermejo, et al. which provided evidence that COVID-19 heart disease was a direct effect on the heart by SARS-CoV-2. This was suspected since cardiac myocytes express the ACE2 protein needed for viral entry into the cells. The authors described robust and specific change in cell cultured cardiomyocytes which corresponded to the changes they observed in autopsies of patients with COVID-19. Thus, the virus can also attack and destroy the heart directly, not just indirectly with hemodynamic stress, hypoxemia and small vessel thrombosis. The third report was by Reynolds, et al., and offered an explanation for the perplexing clinical finding that COVID-19 asymptomatic patients have no pulmonary symptoms but are still hypoxic, indicating something major may be taking place. This finding is so common, that there was even discussion in the news media regarding pulse oximeters and if they should be purchased to detect infections with SARS-CoV-2. Reynolds, et al. noted that there is a disconnect between gas exchange and lung mechanics in COVID-19 pneumonia. In other words, the patients decreased oxygenation does not correspond to the patients ability to breathe. Much like what has been observed in asymptomatic patients. The authors drew similarities to what is observed in hepatopulmonary syndrome and using a contrast enhanced doppler they were able to postulate pulmonary vascular dilatation with resultant increased blood flow which could account for the ventilation-perfusion mismatch and hypoxemia. Thus, the once thought asymptomatic patients who luckily dodged a bullet and were spared from the ravages of the disease, may indeed be truly sick. A significant portion of them may develop myocarditis along with vascular vasodilation with resultant hypoxemia. This pathological process could easily be more significant than the pulmonary effects of the virus, since it is present in both symptomatic and asymptomatic patients. And could explain the debilitating symptoms of fatigue and mental fog which long-haulers are experiencing, many of which had a mild initial illness. These findings underscore the utmost importance for infection preventionists to advocate for the identification of asymptomatic COVID-19 carriers. Infection preventionists need to be able to articulate to those who feel that the young are safe just because their fatality rate is extremely low, that even in this age group there are major concerns regarding long-term consequences of this virus. We need to take this virus seriously. | |||||||
| 9:09 AM 9/8/2020 - Is COVID-19 Primarily a Heart and Vascular Diseases? - Michael Novakhov - SharedNewsLinks - All Saved Stories | |||||||
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Also, it is a well-known fact that generic hair testing has around three months to detect drugs about a week after consumption. At the same time, a urine test can detect marijuana metabolites from three days to a month. Even though this test is called a hair follicle test, lab scientists do not test the follicle or, in layman's terms, the root itself. Instead, hair drug testing is performed on the first inch and a half of the shaft from the point of growth. When the candidate ingests the drug, it gets infused into the bloodstream, which circulates it to the different parts of the body, including the scalp. Here, the deposited metabolites stay until the hair strands are shed or cut off. This is where the testers find the evidence of drug consumption within 90 days. There is no definitive list of fields that perform hair drug analysis. It simply depends on the employer’s choice or the company's policies.For you to fail this test, your urine sample needs to contain 50ng/ml or more THC.The easiest way to prepare your body for a urine test is by flushing out the toxins. The urine test is conducted in two steps. The first one is an immunoassay test, which may show false positives, too. [This is why you may test positive even if you consume full-spectrum CBD or Delta-8 THC products.] This is why, sometimes, the authorities may consider conducting another test known as a gas chromatography test, which is used to detect traces of THC in your system.Hair follicle tests employ two steps.
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